Gemma Currie

TL;DR: Investigating whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease found no effect on endothelial function.

TL;DR: This study recruited people with type 2 diabetes, normal urinary albumin excretion, and preserved renal function from 15 specialist centres in ten European countries and tested whether a urinary proteomic risk classifier (CKD273) score was associated with development of microalbuminuria and whether progression to micro Albuminuria could be prevented with the mineralocorticoid receptor antagonist spironolactone.

TL;DR: Mineralocorticoid receptor antagonism reduces blood pressure and urinary protein/albumin excretion with a quantifiable risk of hyperkalaemia above predefined study upper limit.

TL;DR: This first new biomarker-directed intervention trial aiming at primary prevention of diabetic nephropathy may pave the way for personalised medicine approaches in treatment of diabetes complications.

TL;DR: This review will address the prognostic implications of proteinuria in the general population as well as other specific disease states including diabetes, hypertension and heart failure and review therapeutic strategies that should be considered for patients with persistent proteinuria.