G
Gentaro Ikeda
Researcher at Stanford University
Publications - 7
Citations - 217
Gentaro Ikeda is an academic researcher from Stanford University. The author has contributed to research in topics: Induced pluripotent stem cell & Ischemic cardiomyopathy. The author has an hindex of 4, co-authored 7 publications receiving 66 citations.
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Journal ArticleDOI
Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.
Gentaro Ikeda,Michelle R. Santoso,Yuko Tada,Albert M. Li,Evgeniya Vaskova,Ji Hye Jung,Connor O'Brien,Elizabeth S. Egan,Jiangbin Ye,Phillip C. Yang +9 more
TL;DR: In this paper, extracellular vesicle (EV)-mediated transfer of autologous mitochondria and their related energy source enhance cardiac function through restoration of myocardial bioenergetics.
Journal ArticleDOI
Exosomes From Induced Pluripotent Stem Cell-Derived Cardiomyocytes Promote Autophagy for Myocardial Repair.
Michelle R. Santoso,Gentaro Ikeda,Yuko Tada,Ji Hye Jung,Evgeniya Vaskova,Raymond G. Sierra,Cornelius Gati,Andrew B. Goldstone,Daniel von Bornstaedt,Praveen K. Shukla,Joseph C. Wu,Soichi Wakatsuki,Y. Joseph Woo,Phillip C. Yang +13 more
TL;DR: iCM‐Ex improve post–myocardial infarction cardiac function by regulating autophagy in hypoxic cardiomyoytes, enabling a cell‐free, patient‐specific therapy for ischemic cardiopathy.
Journal ArticleDOI
Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR‐181a in a Rodent Chronic Myocardial Infarction Model
TL;DR: It is demonstrated that an additional mechanism of action of the pleiotropic effects of sacubitril/valsartan may be mediated by the modulation of the miRNA expression level in the exosome payload.
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Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.
Connor O'Brien,Mehmet Ozgun Ozen,Gentaro Ikeda,Evgeniya Vaskova,Ji Hye Jung,Nathan Bayardo,Michelle R. Santoso,Liye Shi,Christine Wahlquist,Zewen Jiang,Yunshin Jung,Yitian Zeng,Elizabeth S. Egan,Robert Sinclair,Adrian P. Gee,Ronald M. Witteles,Mark Mercola,Katrin J. Svensson,Utkan Demirci,Phillip C. Yang +19 more
TL;DR: An in vitro clinical trial evaluating the efficacy and putative mechanisms of SENECA trial–specific MSCs in treating doxorubicin (DOX) injury suggested a mechanism by which MSC's may improve cardiovascular performance in AIC independent of regeneration, which could inform future trial design evaluating the therapeutic potential of M SCs.
Journal ArticleDOI
miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury.
Ji Hye Jung,Gentaro Ikeda,Yuko Tada,Daniel von Bornstädt,Michelle R. Santoso,Christine Wahlquist,Siyeon Rhee,Young-Jun Jeon,Anthony C. Yu,Connor O'Brien,Kristy Red-Horse,Eric A. Appel,Mark Mercola,Joseph Woo,Phillip C. Yang +14 more
TL;DR: In this article, the miR-106a-363 cluster (miR cluster) was found to improve the survival and contractility of hypoxia-injured iCMs and maintained the left-ventricular (LV) chamber size.