Journal ArticleDOI
Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.
Gentaro Ikeda,Michelle R. Santoso,Yuko Tada,Albert M. Li,Evgeniya Vaskova,Ji Hye Jung,Connor O'Brien,Elizabeth S. Egan,Jiangbin Ye,Phillip C. Yang +9 more
TLDR
In this paper, extracellular vesicle (EV)-mediated transfer of autologous mitochondria and their related energy source enhance cardiac function through restoration of myocardial bioenergetics.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2021-03-02. It has received 60 citations till now. The article focuses on the topics: Mitochondrial biogenesis & Mitochondrion.read more
Citations
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Extracellular vesicles as a next-generation drug delivery platform.
TL;DR: In this paper, the authors discuss the biological role of extracellular vesicles and how they can be applied as drug carriers, focusing on the current state of their manufacturing and existing challenges.
Journal ArticleDOI
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies.
Pol Escudé Martinez de Castilla,Lingjun Tong,Chenyuan Huang,Alexandros Marios Sofias,Giorgia Pastorin,Xiaoyuan Chen,Gert Storm,Raymond M. Schiffelers,Jiong-Wei Wang +8 more
TL;DR: In this paper, extracellular vesicles (EVs) have emerged as an attractive drug delivery system and the authors assess their pre-clinical applications, in the form of a systematic review.
Journal ArticleDOI
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities.
Bethany Claridge,Bethany Claridge,Jonathan Lozano,Jonathan Lozano,Qi Hui Poh,Qi Hui Poh,David W. Greening +6 more
TL;DR: Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their endogenous characteristics, however, further bioengineering refinement is required to address clinical and commercial limitations as discussed by the authors.
Journal ArticleDOI
Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612.
Lite Ge,Lite Ge,Chengfeng Xun,Wenshui Li,Shengyu Jin,Zuo Liu,Yi Zhuo,Da Duan,Zhiping Hu,Ping Chen,Ming Lu +10 more
TL;DR: In this article, the effects of extracellular vesicles (EVs) derived from human hypoxic olfactory mucosa MSCs (OM-MSCs) on angiogenesis and its underlying mechanism were explored.
Journal ArticleDOI
Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.
Connor O'Brien,Mehmet Ozgun Ozen,Gentaro Ikeda,Evgeniya Vaskova,Ji Hye Jung,Nathan Bayardo,Michelle R. Santoso,Liye Shi,Christine Wahlquist,Zewen Jiang,Yunshin Jung,Yitian Zeng,Elizabeth S. Egan,Robert Sinclair,Adrian P. Gee,Ronald M. Witteles,Mark Mercola,Katrin J. Svensson,Utkan Demirci,Phillip C. Yang +19 more
TL;DR: An in vitro clinical trial evaluating the efficacy and putative mechanisms of SENECA trial–specific MSCs in treating doxorubicin (DOX) injury suggested a mechanism by which MSC's may improve cardiovascular performance in AIC independent of regeneration, which could inform future trial design evaluating the therapeutic potential of M SCs.
References
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Journal ArticleDOI
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Clyde W. Yancy,Mariell Jessup,Biykem Bozkurt,Javed Butler,Donald E. Casey,Mark H. Drazner,Gregg C. Fonarow,Stephen A. Geraci,Tamara B. Horwich,James L. Januzzi,Maryl R. Johnson,Edward K. Kasper,Wayne C. Levy,Frederick A. Masoudi,Patrick E. McBride,John J.V. McMurray,Judith E. Mitchell,Pamela N. Peterson,Barbara Riegel,Flora Sam,Lynne W. Stevenson,W.H. Wilson Tang,Emily J. Tsai,Bruce L. Wilkoff +23 more
TL;DR: In this article, Anderson et al. proposed a new FAHA Chair, Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect, Alice K. Jacobs et al., this article and Biykem Bozkurt.
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The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
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