C
Christine Wahlquist
Researcher at Stanford University
Publications - 10
Citations - 802
Christine Wahlquist is an academic researcher from Stanford University. The author has contributed to research in topics: Contractility & Induced pluripotent stem cell. The author has an hindex of 5, co-authored 10 publications receiving 632 citations. Previous affiliations of Christine Wahlquist include Discovery Institute & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Inhibition of miR-25 improves cardiac contractility in the failing heart
Christine Wahlquist,Dongtak Jeong,Agustin Rojas-Muñoz,Changwon Kho,Ahyoung Lee,Shinichi Mitsuyama,Alain van Mil,Woo Jin Park,Joost P.G. Sluijter,Pieter A. Doevendans,Roger J. Hajjar,Mark Mercola +11 more
TL;DR: High-throughput functional screening of the human microRNAome reveals that increased expression of endogenous miR-25 contributes to declining cardiac function during heart failure and suggests that it might be targeted therapeutically to restore function.
Journal ArticleDOI
Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation
Nathan Salomonis,Christopher R. Schlieve,Laura Pereira,Christine Wahlquist,Alexandre R. Colas,Alexander C. Zambon,Karen Vranizan,Matthew J. Spindler,Alexander R. Pico,Melissa S. Cline,Tyson A. Clark,Alan Williams,John E. Blume,Eva Samal,Mark Mercola,Bradley J. Merrill,Bruce R. Conklin +16 more
TL;DR: A critical role for AS is illustrated in the specification of ES cells with differentiation, and the utility of global functional analyses of AS is highlighted.
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Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.
Dennis Schade,Marion Lanier,Erik Willems,Karl J. Okolotowicz,Paul J. Bushway,Christine Wahlquist,Cynthia Gilley,Mark Mercola,John R. Cashman +8 more
TL;DR: A medium-throughput murine embryonic stem cell (mESC)-based high-content screening of 17000 small molecules for cardiogenesis led to the identification of a b-annulated 1,4-dihydropyridine that inhibited transforming growth factor β (TGFβ)/Smad signaling by clearing the type II TGFβ receptor from the cell surface.
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Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR‐181a in a Rodent Chronic Myocardial Infarction Model
TL;DR: It is demonstrated that an additional mechanism of action of the pleiotropic effects of sacubitril/valsartan may be mediated by the modulation of the miRNA expression level in the exosome payload.
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miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure
Dongtak Jeong,Jimeen Yoo,Philyoung Lee,Sacha V. Kepreotis,Ahyoung Lee,Christine Wahlquist,Brian D. Brown,Changwon Kho,Mark Mercola,Roger J. Hajjar +9 more
TL;DR: Tough Decoy (TuD) inhibitors are emerging as a highly effective method for microRNA inhibition due to their resistance to endonucleolytic degradation, high miRNA binding affinity, and efficient delivery and data indicate that miR-25 TuD is an effective long-term suppressor of mi R-25 and a promising therapeutic candidate to treat heart failure.