G
Georg J. Furtmüller
Researcher at Johns Hopkins University School of Medicine
Publications - 34
Citations - 678
Georg J. Furtmüller is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Transplantation & Vascularized Composite Allotransplantation. The author has an hindex of 11, co-authored 32 publications receiving 531 citations. Previous affiliations of Georg J. Furtmüller include Johns Hopkins University.
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Journal ArticleDOI
Preventing Allograft Rejection by Targeting Immune Metabolism
Chen Fang Lee,Chen Fang Lee,Ying-Chun Lo,Chih Hsien Cheng,Chih Hsien Cheng,Georg J. Furtmüller,Byoung Chol Oh,Vinicius Andrade-Oliveira,Ajit G. Thomas,Caitlyn E. Bowman,Barbara S. Slusher,Michael J. Wolfgang,Gerald Brandacher,Jonathan D. Powell +13 more
TL;DR: An anti-rejection regimen involving the glycolytic inhibitor 2-deoxyglucose (2-DG), the anti-type II diabetes drug metformin, and the inhibitor of glutamine metabolism 6-diazo-5-oxo-L-norleucine (DON) was able to prevent or delay graft rejection in fully mismatched skin and heart allograft transplantation models.
Journal ArticleDOI
A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels
Daniel J. Smith,Gabriel A. Brat,Scott H. Medina,Dedi Tong,Yong Huang,Johanna Grahammer,Georg J. Furtmüller,Byoung Chol Oh,Katelyn Nagy-Smith,Katelyn Nagy-Smith,Piotr Walczak,Gerald Brandacher,Joel P. Schneider +12 more
TL;DR: A multi-phase transitioning peptide hydrogel that can be injected into the lumen of vessels to facilitate suturing is reported, adding a new tool to the armamentarium for micro- and supermicrosurgical procedures.
Journal ArticleDOI
Mesenchymal Stem Cells Enhance Nerve Regeneration in a Rat Sciatic Nerve Repair and Hindlimb Transplant Model.
Damon S. Cooney,Eric G. Wimmers,Zuhaib Ibrahim,Johanna Grahammer,Joani M. Christensen,Gabriel A. Brat,Lehao W. Wu,Karim A. Sarhane,Joseph Lopez,Christoph Wallner,Georg J. Furtmüller,Nance Yuan,John Pang,Kakali Sarkar,W. P. Andrew Lee,Gerald Brandacher +15 more
TL;DR: Local and systemic MSC injections significantly improve the pace and degree of nerve regeneration after nerve injury and hindlimb transplantation and resulted in improved nerve regeneration following allogeneic hind Limb transplants.
Journal ArticleDOI
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders
Michael T. Nedelcovych,Lukáš Tenora,Boe-Hyun Kim,Jennifer Kelschenbach,Wei Chao,Eran Hadas,Andrej Jančařík,Eva Prchalova,Sarah C. Zimmermann,Ranjeet Prasad Dash,Alexandra J. Gadiano,Caroline Garrett,Georg J. Furtmüller,Byoung Chol Oh,Gerald Brandacher,Jesse Alt,Pavel Majer,David J. Volsky,Rana Rais,Barbara S. Slusher +19 more
TL;DR: It is shown that the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON, 14) attenuates glutamate synthesis in HIV-infected microglia/macrophages, offering therapeutic potential for HAND.
Journal ArticleDOI
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival
Baharak Bahmani,Mayuko Uehara,Liwei Jiang,Farideh Ordikhani,Naima Banouni,Takaharu Ichimura,Zhabiz Solhjou,Georg J. Furtmüller,Gerald Brandacher,David Alvarez,Ulrich H. von Andrian,Kenji Uchimura,Qiaobing Xu,Ishaan Vohra,Osman A. Yilmam,Yousef Haik,Jamil Azzi,Vivek Kasinath,Jonathan S. Bromberg,Martina M. McGrath,Reza Abdi +20 more
TL;DR: A nanoparticle (NP) is synthesized as a carrier of anti-CD3, and the conjugation strategy to coat the NP surface with MECA79 mAb (MECA79-anti- CD3-NP) to enhance LN accumulation is optimized to redefine the methods of administering immune therapeutics in transplantation.