Georg Waeg

TL;DR: Evidence is provided that 4-hydroxynonenal (HNE), an aldehydic product of membrane lipid peroxidation, is a key mediator of neuronal apoptosis induced by oxidative stress and that the antiapoptotic action of glutathione may involve detoxification of HNE.

TL;DR: Alpha-tocopherol is an important, yet not the only parameter that determines the oxidation resistance of LDL, and by supplementating plasma with vitamin E, the alpha-tocaperol content of LDL could be increased from approximately 9 to 30 mol/mol LDL and also the oxidative resistance increased nearly linearly with increasing alpha-ocopherol content.

TL;DR: In vivo results indicate that HSL is the rate-limiting enzyme for the cellular catabolism of DG in adipose tissue and muscle implying a substrate specificity of the enzyme in vivo.

TL;DR: Density centrifugation of plaque homogenates and Western blot analysis showed that, in the apo B-containing lipoprotein fraction, the mAb recognized protein(s) of molecular mass greater than apoB, similar to those produced during oxidation of LDL with HOCl in vitro.

TL;DR: It is shown that in humans the oxidation resistance of LDL can be increased by vitamin E supplementation and the association was seen between levels of carotenoids and vitamin E in plasma and LDL.