George A. Ferron

TL;DR: The ALICE is a useful tool for dose-controlled nanoparticle (or solute) exposure of cells at the air-liquid interface and indicates that ZnO nanoparticles are not toxic at occupationally allowed exposure levels.

TL;DR: There is a small but consistent significant proinflammatory effect of this exposure to ultrafine particles that is greater than the effect of the same exposure to fine CB, which was associated with significant increases in the total numbers of blood leukocytes.

TL;DR: The current knowledge on the dosimetry of inhaled particles (including UfPs) is summarized with a focus on recent data on translocation of UfP into secondary target organs suggesting that the lifetime dose of ambient UFPs insecondary target organs is about 1011 particles.

TL;DR: No adverse effects from gold NPs were observed in a triple cell co-culture model simulating the alveolar lung epithelium, and chronic studies under in vivo conditions are needed to entirely exclude adverse effects.

TL;DR: The geometry of commercially available perfusion chambers designed for harbouring three membrane-based cell cultures was modified for reliable and dose-controlled air-liquid interface (ALI) exposures to reveal a sensitive antioxidant and stress response, while cell viability did not reveal a toxic mechanism.