G
George Coukos
Researcher at Ludwig Institute for Cancer Research
Publications - 463
Citations - 49514
George Coukos is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Ovarian cancer & Immunotherapy. The author has an hindex of 87, co-authored 426 publications receiving 41199 citations. Previous affiliations of George Coukos include Hospital of the University of Pennsylvania & University of Glasgow.
Papers
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Journal ArticleDOI
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J. Curiel,George Coukos,Linhua Zou,Xavier Alvarez,Pui Cheng,Peter Mottram,Melina Evdemon-Hogan,Jose R. Conejo-Garcia,Lin Zhang,Matthew E. Burow,Yun Zhu,Shuang Wei,Ilona Kryczek,Ben Daniel,Alan N. Gordon,Leann Myers,Andrew A. Lackner,Mary L. Disis,Keith L. Knutson,Lieping Chen,Weiping Zou +20 more
TL;DR: It is shown, in detailed studies of CD4+CD25+FOXP3+ Treg cells in 104 individuals affected with ovarian carcinoma, that human tumor T Reg cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo.
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Cancer immunotherapy comes of age
TL;DR: In the context of advances in the understanding of how tolerance, immunity and immunosuppression regulate antitumour immune responses, these successes suggest that active immunotherapy represents a path to obtain a durable and long-lasting response in cancer patients.
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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang,Jose R. Conejo-Garcia,Dionyssios Katsaros,Phyllis A. Gimotty,Marco Massobrio,Giorgia Regnani,Antonis Makrigiannakis,Heidi J. Gray,Katia Schlienger,Michael N. Liebman,Stephen C. Rubin,George Coukos +11 more
TL;DR: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma and was associated with increased expression of interferon-gamma, interleukin-2, and lymphocyte-attracting chemokines within the tumor.
Journal ArticleDOI
Laser-capture microdissection
Virginia Espina,Julia Wulfkuhle,Valerie S. Calvert,Amy VanMeter,Weidong Zhou,George Coukos,David Geho,Emanuel F. Petricoin,Lance A. Liotta +8 more
TL;DR: A thorough description of laser-capture microdissection techniques is provided, with an emphasis on tips and troubleshooting advice derived from LCM users.
Journal Article
Regulatory CD4+CD25+ T Cells in Tumors from Patients with Early-Stage Non-Small Cell Lung Cancer and Late-Stage Ovarian Cancer
Edward Y. Woo,Christina S. Chu,Theresa J. Goletz,Katia Schlienger,Heidi Yeh,George Coukos,Stephen C. Rubin,Larry R. Kaiser,Carl H. June +8 more
TL;DR: T tumor-associated T cells from patients with early and late-stage epithelial tumors contain increased proportions of CD4(+)CD25(+) T cells that secrete the immunosuppressive cytokine transforming growth factor-beta, consistent with the phenotype of regulatory T cells.