T
Tyler J. Curiel
Researcher at University of Texas at Austin
Publications - 204
Citations - 20361
Tyler J. Curiel is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 55, co-authored 180 publications receiving 18381 citations. Previous affiliations of Tyler J. Curiel include Baylor University Medical Center & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J. Curiel,George Coukos,Linhua Zou,Xavier Alvarez,Pui Cheng,Peter Mottram,Melina Evdemon-Hogan,Jose R. Conejo-Garcia,Lin Zhang,Matthew E. Burow,Yun Zhu,Shuang Wei,Ilona Kryczek,Ben Daniel,Alan N. Gordon,Leann Myers,Andrew A. Lackner,Mary L. Disis,Keith L. Knutson,Lieping Chen,Weiping Zou +20 more
TL;DR: It is shown, in detailed studies of CD4+CD25+FOXP3+ Treg cells in 104 individuals affected with ovarian carcinoma, that human tumor T Reg cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo.
Journal ArticleDOI
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Tyler J. Curiel,Shuang Wei,Haidong Dong,Xavier Alvarez,Pui Cheng,Peter Mottram,Roman Krzysiek,Keith L. Knutson,Ben Daniel,Maria Carla Zimmermann,Odile David,Matthew E. Burow,Alan N. Gordon,Nina Dhurandhar,Leann Myers,Ruth E. Berggren,Akseli Hemminki,Ronald D. Alvarez,Dominique Emilie,David T. Curiel,Lieping Chen,Weiping Zou +21 more
TL;DR: It is shown that a fraction of blood monocyte-derived myeloid dendritic cells (MDCs) express B7-H1, a member of the B7 family, on the cell surface, which could be further upregulated by tumor environmental factors.
Journal ArticleDOI
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes.
Terri H. Finkel,G. Tudor-Williams,Nirmal K. Banda,Mark F. Cotton,Tyler J. Curiel,Colin R. F. Monks,Colin R. F. Monks,Timothy W. Baba,Timothy W. Baba,Ruth M. Ruprecht,Abraham Kupfer +10 more
TL;DR: It is shown, using in situ labelling of lymph nodes from HIV- infected children and SIV-infected macaques, that apoptosis occurs predominantly in bystander cells and not in the productively infected cells themselves, arguing that rational drug therapy may involve combination agents targeting viral replication in infected cells and apoptosis of uninfected cells.
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B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
Ilona Kryczek,Ilona Kryczek,Linhua Zou,Linhua Zou,Paulo C. Rodriguez,Gefeng Zhu,Shuang Wei,Shuang Wei,Peter Mottram,Michael J. Brumlik,Pui Cheng,Tyler J. Curiel,Leann Myers,Andrew A. Lackner,Xavier Alvarez,Augusto C. Ochoa,Lieping Chen,Weiping Zou,Weiping Zou +18 more
TL;DR: B7-H4+ tumor macrophages constitute a novel suppressor cell population in ovarian cancer and represent a critical checkpoint in determining host responses to dysfunctional cytokines in ovariancancer.
Journal ArticleDOI
Safety and Efficacy of Durvalumab (MEDI4736), an Anti–Programmed Cell Death Ligand-1 Immune Checkpoint Inhibitor, in Patients With Advanced Urothelial Bladder Cancer
Christophe Massard,Michael S. Gordon,Sunil Sharma,Saeed Rafii,Zev A. Wainberg,Jason J. Luke,Tyler J. Curiel,Gerardo Colon-Otero,Omid Hamid,Rachel E. Sanborn,Peter H. O'Donnell,Alexandra Drakaki,Winston Tan,John Kurland,Marlon Rebelatto,Xiaoping Jin,John A. Blake-Haskins,Ashok Kumar Gupta,Neil H. Segal +18 more
TL;DR: Durvalumab demonstrated a manageable safety profile and evidence of meaningful clinical activity in PD-L1-positive patients with UBC, many of whom were heavily pretreated.