L
Linhua Zou
Researcher at Tulane University
Publications - 10
Citations - 7864
Linhua Zou is an academic researcher from Tulane University. The author has contributed to research in topics: Tumor microenvironment & T cell. The author has an hindex of 9, co-authored 10 publications receiving 7345 citations. Previous affiliations of Linhua Zou include University of Michigan.
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Journal ArticleDOI
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J. Curiel,George Coukos,Linhua Zou,Xavier Alvarez,Pui Cheng,Peter Mottram,Melina Evdemon-Hogan,Jose R. Conejo-Garcia,Lin Zhang,Matthew E. Burow,Yun Zhu,Shuang Wei,Ilona Kryczek,Ben Daniel,Alan N. Gordon,Leann Myers,Andrew A. Lackner,Mary L. Disis,Keith L. Knutson,Lieping Chen,Weiping Zou +20 more
TL;DR: It is shown, in detailed studies of CD4+CD25+FOXP3+ Treg cells in 104 individuals affected with ovarian carcinoma, that human tumor T Reg cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo.
Journal ArticleDOI
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
Ilona Kryczek,Ilona Kryczek,Linhua Zou,Linhua Zou,Paulo C. Rodriguez,Gefeng Zhu,Shuang Wei,Shuang Wei,Peter Mottram,Michael J. Brumlik,Pui Cheng,Tyler J. Curiel,Leann Myers,Andrew A. Lackner,Xavier Alvarez,Augusto C. Ochoa,Lieping Chen,Weiping Zou,Weiping Zou +18 more
TL;DR: B7-H4+ tumor macrophages constitute a novel suppressor cell population in ovarian cancer and represent a critical checkpoint in determining host responses to dysfunctional cytokines in ovariancancer.
Journal Article
CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers
Ilona Kryczek,Andrzej Lange,Peter Mottram,Xavier Alvarez,Pui Cheng,Melina Hogan,Lieve Moons,Shuang Wei,Linhua Zou,Véronique Machelon,Dominique Emilie,Margarita Terrassa,Andrew A. Lackner,Tyler J. Curiel,Peter Carmeliet,Weiping Zou +15 more
TL;DR: It is shown that hypoxia synchronously induces tumor CXCL12 and VEGF production and form a synergistic angiogenic axis in vivo, which will be a novel efficient antiangiogenesis strategy to treat cancer.
Journal ArticleDOI
Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.
Linhua Zou,Brian G. Barnett,Hana Safah,Vincent F. LaRussa,Melina Evdemon-Hogan,Peter Mottram,Shuang Wei,Odile David,Tyler J. Curiel,Weiping Zou +9 more
TL;DR: Findings show a mechanism for homeostatic Treg trafficking and indicate that bone marrow is a significant reservoir for Tregs, and suggest a novel mechanism explaining reduced acute graft-versus-host disease and improvement in autoimmune diseases following G-CSF treatment.
Journal ArticleDOI
Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment
Ilona Kryczek,Shuang Wei,Linhua Zou,Saleh Altuwaijri,Wojciech Szeliga,Jay K. Kolls,Alfred E. Chang,Weiping Zou +7 more
TL;DR: It is shown that IL-2 reduces IL-17+ T cell differentiation in the tumor microenvironment accompanied with an enhanced Treg cell compartment in vitro and in vivo, and this work reveals a novel role for IL-1 in controlling the balance between IL- 17+ and Treg cells.