George L. Kenyon

TL;DR: In this paper, an autoinducer excreted by Photobacterium fischeri strain MJ-1 was isolated from the cell-free medium by extraction with ethyl acetate, evaporation of solvent, workup with ethanol-water mixtures, and silica gel chromatography.

TL;DR: The ability of C[sub 60] fullerene derivatives to interact with the active site of HIV-1 protease (HIVP) has been examined through model building and simple physical chemical analysis as discussed by the authors.

TL;DR: In this article, a diamido diacid diphenyl fulleroid derivative was designed specifically to inhibit an HIV enzyme and detailed synthesis and mass spectrometric analysis of the water-soluble, biologically active methanofullerene are described.

TL;DR: Structural relationships (SAR) of the chalcones in the context of a homology-based model structure of the malaria trophozoite cysteine protease, the most likely target enzyme, are presented, suggesting that this series will be active against chloroquine-resistant malaria.

TL;DR: A superfamily of enzymes related by their ability to catalyze the abstraction of the alpha-proton of a carboxylic acid to form an enolic intermediate is discovered, and the established and deduced structure-function relationships in the superfamily allow the prediction that other apparent members of the family for which no catalytic functions have yet been assigned will also perform chemistry involving abstraction of their alpha-protons.