G
George L. Mutter
Researcher at Brigham and Women's Hospital
Publications - 147
Citations - 11589
George L. Mutter is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Endometrial intraepithelial neoplasia & Endometrial cancer. The author has an hindex of 55, co-authored 145 publications receiving 10954 citations. Previous affiliations of George L. Mutter include NewYork–Presbyterian Hospital & Case Western Reserve University.
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Journal ArticleDOI
Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies
James V. Lacey,George L. Mutter,Marisa R. Nucci,Brigitte M. Ronnett,Olga B. Ioffe,Brenda B. Rush,Andrew G. Glass,Douglas A. Richesson,Nilanjan Chatterjee,Bryan Langholz,Mark E. Sherman +10 more
TL;DR: The authors estimated progression risk associated with EIN among endometrial biopsies in a nested case‐control study of EH progression in order to guide clinical management.
Journal ArticleDOI
Evidence for a Latent Precursor (p53 Signature) that May Precede Serous Endometrial Intraepithelial Carcinoma
Elke A. Jarboe,Ellen S. Pizer,Alexander Miron,Nick Monte,George L. Mutter,Christopher P. Crum +5 more
TL;DR: This is the first description of p53 signatures adjacent to carcinoma, suggesting a role for this entity in the genesis of serous malignancy and the role of the p53 signature in early serous neoplasia is discussed.
Journal ArticleDOI
Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression
Jan P. A. Baak,Jan P. A. Baak,Bianca van Diermen,Anita Steinbakk,Emiel A. M. Janssen,Ivar Skaland,George L. Mutter,Bent Fiane,Kjell Løvslett +8 more
TL;DR: It is concluded that loss of PTEN expression is the first biomarker in EIN that increases the accuracy of the prognostic DS to predict cancer progression risk, unless endometrial hyperplasias are stratified by histological morphometric D-Score, which has a low positive predictive value.
Journal ArticleDOI
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
TL;DR: K-ras mutation occurs in both premalignant microsatellite stable and unstable endometrial neoplasia, sometimes before acquisition of features readily diagnostic as atypicalendometrial hyperplasia.
Journal ArticleDOI
The sex ratio of normal and manipulated human sperm quantitated by the polymerase chain reaction
TL;DR: In this article, the primary sex ratio, the relative abundance of X and Y chromosomebearing sperm, in unselected sperm and in sperm selected by swim-up or Sephadex filtration (SpermPrep column), was established.