George Taleo

TL;DR: The issues faced and the solutions found in developing this robust strategic partnership between national programmes and research partners within the APMEN Vivax Working Group are described.

TL;DR: High community involvement as measured by drug compliance and bednet provision has resulted in sustained interruption of malaria transmission in Aneityum, suggesting malaria can be eliminated on isolated islands with well-adapted short-term mass drug administration and sustained vector control if there is a high degree of community participation.

TL;DR: Seroepidemiology can provide key information on malaria transmission for control programmes, when parasite rates are low, and as Vanuatu moves closer to malaria elimination, monitoring changes in transmission intensity and identification of residual malaria foci is paramount in order to concentrate intervention efforts.

TL;DR: In low malaria transmission settings, a package for augmenting social capital and sustaining community participation for elimination will be essential and includes: 'sentinel sites' for qualitative monitoring of evolving local socio-cultural, behavioural and practical issues that impact malaria prevention and treatment.

TL;DR: The data demonstrate an association between CYP2C19 mutations and poor metabolism of proguanil and the trend towards the existence of a gene dose effect is demonstrated.