G
Georges Offenstadt
Researcher at French Institute of Health and Medical Research
Publications - 103
Citations - 3952
Georges Offenstadt is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Intensive care & Intensive care unit. The author has an hindex of 32, co-authored 103 publications receiving 3655 citations. Previous affiliations of Georges Offenstadt include Pierre-and-Marie-Curie University & University of Paris.
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Journal ArticleDOI
TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice
Yu Wang,Hafid Ait-Oufella,Olivier Herbin,Philippe Bonnin,Bhama Ramkhelawon,Soraya Taleb,Jin Huang,Georges Offenstadt,Christophe Combadière,Laurent Rénia,Jason L. Johnson,Pierre-Louis Tharaux,Alain Tedgui,Ziad Mallat +13 more
TL;DR: A critical role for TGF-beta is identified in the taming of the innate immune response and the preservation of vessel integrity in C57BL/6 mice, which contrasts with its reported pathogenic role in Marfan syndrome.
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Mottling score predicts survival in septic shock
Hafid Ait-Oufella,S. Lemoinne,Pierre-Yves Boëlle,Pierre-Yves Boëlle,Arnaud Galbois,Jean-Luc Baudel,J. Lemant,Jérémie Joffre,Dimitri Margetis,Bertrand Guidet,Bertrand Guidet,Eric Maury,Eric Maury,Georges Offenstadt,Georges Offenstadt +14 more
TL;DR: The mottling score as well as its variation during resuscitation is a strong predictor of 14-day survival in patients with septic shock, and the mean arterial pressure, central venous pressure and cardiac index were not.
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The endothelium: physiological functions and role in microcirculatory failure during severe sepsis.
Hafid Ait-Oufella,Eric Maury,Eric Maury,S. Lehoux,Bertrand Guidet,Bertrand Guidet,Georges Offenstadt,Georges Offenstadt +7 more
TL;DR: The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of new vessels during severe sepsis.
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Cirrhotic patients in the medical intensive care unit: early prognosis and long-term survival.
Vincent Das,Pierre-Yves Boëlle,Arnaud Galbois,Bertrand Guidet,Eric Maury,Nicolas Carbonell,Richard Moreau,Georges Offenstadt +7 more
TL;DR: In-hospital survival rate of intensive care unit-admitted cirrhotic patients seemed acceptable, even in patients requiring life-sustaining treatments and/or with multiple organ failure on admission, and a trial of unrestricted intensive care for a few days could be proposed for select critically ill cirrhosis patients.
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Availability of an alcohol solution can improve hand disinfection compliance in an intensive care unit.
Eric Maury,Marc Alzieu,Jean Luc Baudel,Norredine Haram,Frédéric Barbut,Bertrand Guidet,Georges Offenstadt +6 more
TL;DR: It is suggested that rubbing with alcohol solution increases compliance with hand disinfection, and that it could be proposed as an alternative to conventional handwashing in the MICU.