C
Christophe Combadière
Researcher at University of Paris
Publications - 165
Citations - 13471
Christophe Combadière is an academic researcher from University of Paris. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 57, co-authored 160 publications receiving 12153 citations. Previous affiliations of Christophe Combadière include National Institutes of Health & French Institute of Health and Medical Research.
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Journal ArticleDOI
International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Christophe Combadière,Joshua M. Farber,Gerard J. Graham,Richard Horuk,Alexander Hovard Sparre-Ulrich,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Christine Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Marcus Thelen,Osamu Yoshie,Albert Zlotnik +22 more
TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).
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Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice
Christophe Combadière,Stephane Potteaux,Mathieu P Rodero,Tabassome Simon,Adeline Pezard,Bruno Esposito,Régine Merval,Amanda E. I. Proudfoot,Alain Tedgui,Ziad Mallat +9 more
TL;DR: It is shown that chemokine-mediated signals critically determine the frequency of monocytes in the blood and bone marrow under both noninflammatory and atherosclerotic conditions and that CCL2, CX3CR1, and CCR5 play independent and additive roles in atherogenesis.
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CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
Christophe Combadière,Charles Feumi,William Raoul,Nicole Keller,Mathieu P Rodero,Adeline Pezard,Sophie Lavalette,Marianne Houssier,Laurent Jonet,Emilie Picard,Patrice Debré,Mirna Sirinyan,Philippe Deterre,Tania Ferroukhi,Salomon-Yves Cohen,Dominique Chauvaud,Jean-Claude Jeanny,Sylvain Chemtob,Francine Behar-Cohen,Florian Sennlaub +19 more
TL;DR: Results show that CX3CR1-dependent accumulation of subretinal MCs evokes cardinal features of AMD and reveal what the authors believe to be a novel pathogenic process with important implications for the development of new therapies for AMD.
Journal ArticleDOI
Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice
Christophe Combadière,Stephane Potteaux,Ji-Liang Gao,Bruno Esposito,Saveria Casanova,Eric J. Lee,Patrice Debré,Alain Tedgui,Philip M. Murphy,Ziad Mallat +9 more
TL;DR: The CX3CR1-CX3CL1 pathway seems to play a direct and critical role in monocyte recruitment and atherosclerotic lesion development in a mouse model of human atherosclerosis.
Journal ArticleDOI
Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine, and Identification of a Specific Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3
Motoji Kitaura,Toshihiro Nakajima,Toshio Imai,Shigenori Harada,Christophe Combadière,H. Lee Tiffany,Philip M. Murphy,Osamu Yoshie +7 more
TL;DR: It is shown that human eotaxin is a potent and highly specific agonist for CC chemokine receptor 3, a G protein-coupled receptor selectively expressed in human eosinophils, and may be good targets for the development of selective drugs for inflammatory diseases where eos inophils contribute to pathogenesis, such as asthma.