Georgia Z. Chen

TL;DR: The findings suggest that tyrosine phosphorylation regulates PKM2 to provide a metabolic advantage to tumor cells, thereby promoting tumor growth.

TL;DR: Inhibition of PGAM1 by shRNA or a small molecule inhibitor PGMI-004A results in increased 3-PG and decreased 2-PG levels in cancer cells, leading to significantly decreased glycolysis, PPP flux and biosynthesis, as well as attenuated cell proliferation and tumor growth.

TL;DR: It is reported that tyrosine phosphorylation enhancesPDHK1 kinase activity by promoting ATP and PDC binding and activates PDHK1 to promote the Warburg effect and tumor growth.

TL;DR: This imaging method may be able to help physicians to dissect malignant regions with a safe margin and to evaluate the tumor bed after resection and may lead to advances in the optical diagnosis of prostate cancer using HSI technology.

TL;DR: The findings suggest that tyrosine phosphorylation enhances LDH-A enzyme activity to promote the Warburg effect and tumor growth by regulating the NADH/NAD+ redox homeostasis, representing an acute molecular mechanism underlying the enhanced lactate production in cancer cells.