G
Gerald M. Liew
Researcher at National University of Singapore
Publications - 7
Citations - 300
Gerald M. Liew is an academic researcher from National University of Singapore. The author has contributed to research in topics: Ecdysone receptor & Ecdysone. The author has an hindex of 5, co-authored 7 publications receiving 242 citations. Previous affiliations of Gerald M. Liew include Raffles Institution & Brown University.
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Journal ArticleDOI
The Intraflagellar Transport Protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3
Gerald M. Liew,Fan Ye,Andrew R. Nager,Murphy Jp,Lee Js,Mike Aguiar,David K. Breslow,Steven P. Gygi,Maxence V. Nachury +8 more
TL;DR: It is proposed that IFT27 separates from IFT-B inside cilia to promote ARL6 activation, BBSome coat assembly, and subsequent ciliary exit, mirroring the process by which BBSome mediates cargo entry into cilia.
Journal ArticleDOI
BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8.
Shinsuke Niwa,Li Tao,Sharon Yuan-Fu Lu,Gerald M. Liew,Wei Feng,Maxence V. Nachury,Kang Shen,Kang Shen +7 more
TL;DR: It is shown that part of the BLOC-1-related complex (BORC), previously shown to regulate lysosomal transport, is required to recruit and activate ARL-8 on SVPs, and that SAM-4/Myrlysin, a subunit of BORC, promotes the GDP-to-GTP exchange of ARl-8 in vitro and recruits ARL
Journal ArticleDOI
Structural connectome alterations in prodromal and de novo Parkinson's disease patients.
Ming-Ching Wen,Hannah S. E. Heng,Jung-Lung Hsu,Jung-Lung Hsu,Zheyu Xu,Gerald M. Liew,Wing Lok Au,Ling Ling Chan,Louis C.S. Tan,Eng-King Tan +9 more
TL;DR: Increased network efficiency and connectivity of proPDs and decreased local connectivity of dPDs might suggest the emergence and dissipation of neural compensation in the prodromal phase and in early PD, respectively.
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Isolation and characterization of the ecdysone receptor and its heterodimeric partner ultraspiracle through development in Sciara coprophila
Michael S. Foulk,John M. Waggener,Janell M. Johnson,Yutaka Yamamoto,Gerald M. Liew,Gerald M. Liew,Fyodor D. Urnov,Fyodor D. Urnov,Yuki Young,Genee Lee,Heidi S. Smith,Susan A. Gerbi +11 more
TL;DR: The isolation, cloning, and characterizing of two ecdysone receptor isoforms in Sciara and the heterodimeric partner, ultraspiracle (ScUSP) are reported, finding that ScEcR-A is the predominant isoform in larval tissues and Sc EcR-B in adult tissues, contrary to the pattern in Drosophila.
Journal ArticleDOI
Mild Parkinsonian Signs in a Community Ambulant Population
Yin Minn Aye,Gerald M. Liew,Samuel Yong-Ern Ng,Ming-Ching Wen,Linda L H Lim,Shu-Ting Chua,Usanee Chotphoksap,Yin Xia Chao,Adeline S Y Ng,Eng-King Tan,Louis C.S. Tan,Zheyu Xu +11 more
TL;DR: MPS is common and closely related to cognitive impairment and increasing age, and the presence of RBD is predictive of higher MPS scores.