G
Gerald Niedobitek
Researcher at University of Erlangen-Nuremberg
Publications - 183
Citations - 12851
Gerald Niedobitek is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Epstein–Barr virus & Virus. The author has an hindex of 62, co-authored 183 publications receiving 12262 citations. Previous affiliations of Gerald Niedobitek include University of Birmingham & Free University of Berlin.
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Journal ArticleDOI
Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages
Mário Henrique M. Barros,Franziska Hauck,Johannes H. Dreyer,Bettina Kempkes,Gerald Niedobitek +4 more
TL;DR: The detection of pSTAT1, RBP-J, and CMAF in the context of CD68 or CD163 expression is a suitable tool for the characterisation of macrophage polarisation in situ, and CD163 cannot be considered a reliable M2 marker when used on its own.
Journal ArticleDOI
Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization.
TL;DR: In situ hybridization revealed that in two HD cases, the EBV infected cells had the distinct morphology of Hodgkin and Reed-Sternberg cells, thus suggesting a direct pathoetiological relationship between EBV and some cases of HD.
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Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells
Hermann Herbst,Friederike Dallenbach,Michael Hummel,Gerald Niedobitek,Stefano Pileri,Nikolaus Müller-Lantzsch,Harald Stein +6 more
TL;DR: The findings support the concept of a pathoetiological role of EBV in many cases of Hodgkin disease and confirm previous studies establishing the presence ofEBV genomes in Hodgkin and Reed-Sternberg cells by demonstrating expression of an EBV-encoded protein in the tumor-cell population.
Journal ArticleDOI
Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.
E M Deacon,G Pallesen,Gerald Niedobitek,John Crocker,L Brooks,Alan B. Rickinson,Lawrence S. Young +6 more
TL;DR: Preliminary results on viral gene expression in HRS cells are extended by adopting polymerase chain reaction-based and in situ hybridization assays capable of detecting specific EBV latent transcripts diagnostic of the different possible forms of EBV latency.
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Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial.
TL;DR: It is shown that all carcinomas and all non-neoplastic epithelial cells, except hepatocytes, parietal cells, and apical cell layers in squamous epithelia, homogeneously expressed Ber-EP4 antigen.