S
Sarah Shefer
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 180
Citations - 8296
Sarah Shefer is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Cholesterol & Bile acid. The author has an hindex of 49, co-authored 180 publications receiving 8039 citations. Previous affiliations of Sarah Shefer include United States Department of Veterans Affairs & North Shore University Hospital.
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Journal ArticleDOI
Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
Clive R. Pullinger,Celeste Eng,Gerald Salen,Sarah Shefer,Ashok K. Batta,Sandra K. Erickson,Andrea Verhagen,Christopher R. Rivera,Sean J. Mulvihill,Mary J. Malloy,John P. Kane +10 more
TL;DR: A new metabolic disorder presenting with hyperlipidemia caused by a homozygous deletion mutation in CYP7A1 is reported, which leads to a frameshift that results in loss of the active site and enzyme function.
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Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism
David Q. Shih,Markus Bussen,Ephraim Sehayek,Meenakshisundaram Ananthanarayanan,Benjamin L. Shneider,Frederick J. Suchy,Sarah Shefer,Jaya S. Bollileni,Frank J. Gonzalez,Jan L. Breslow,Markus Stoffel +10 more
TL;DR: It is demonstrated that Tcf1, in addition to being an important regulator of insulin secretion, is an essential transcriptional regulator of bile acid and HDL-cholesterol metabolism.
Journal ArticleDOI
Long-Term Treatment of Cerebrotendinous Xanthomatosis with Chenodeoxycholic Acid
TL;DR: It is concluded that long-term therapy with chenodeoxycholic acid may correct the biochemical abnormalities and arrest and possibly reverse the progression of cerebrotendinous xanthomatosis.
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Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis.
Gerald Salen,V Shore,G.S. Tint,T Forte,Sarah Shefer,I Horak,E Horak,B. Dayal,Lien B. Nguyen,Ashok K. Batta +9 more
TL;DR: It is postulate that the changes in sitosterol metabolism (increased absorption, loss of tissue sterol structural recognition, expanded pools, and hepatic retention) are a response to reduced cholesterol synthesis in these subject.
Journal ArticleDOI
Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption
Ephraim Sehayek,Jennie G. Ono,Sarah Shefer,Lien B. Nguyen,Nan Wang,Ashok K. Batta,Gerald Salen,Jonathan D. Smith,Alan R. Tall,Jan L. Breslow +9 more
TL;DR: The results suggest that the excretion of cholesterol into the bile plays an important role in regulating the percentage absorption of dietary cholesterol.