Showing papers by "Gerard A. Gioia published in 2012"

Recommendations for the Use of Common Outcome measures in pediatric traumatic brain injury research

Abstract: This article addresses the need for age-relevant outcome measures for traumatic brain injury (TBI) research and summarizes the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup. The Pediatric Workgroup's recommendations address primary clinical research objectives including characterizing course of recovery from TBI, prediction of later outcome, measurement of treatment effects, and comparison of outcomes across studies. Consistent with other Common Data Elements (CDE) Workgroups, the Pediatric TBI Outcomes Workgroup adopted the standard three-tier system in its selection of measures. In the first tier, core measures included valid, robust, and widely applicable outcome measures with proven utility in pediatric TBI from each identified domain including academics, adaptive and daily living skills, family and environment, global outcome, health-related quality of life, infant and toddler measures, language and communication, neuropsychological impairment, physical functioning, ps...

Importance of 'return-to-learn' in pediatric and adolescent concussion.

Abstract: The concept of “return-to-play” after concussion is familiar to pediatricians who routinely care for injured student-athletes. Premature return-to-play of a student-athlete who is still injured from a concussion may result in more severe and potentially long-lasting deficits.1 In contrast, “return-to-learn” plans for student-athletes have not received as much attention, perhaps because so much regarding concussion awareness comes from lay reports of professional athletes who play a sport for their livelihood, as compared with pediatric and adolescent-aged athletes for whom school is their primary “work.” Importance of ‘Return-to-Learn’ in Pediatric and Adolescent Concussion

The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research

Abstract: Learning disabilities and other cognitive disorders represent one of the most important unmet medical needs and a significant source of lifelong disability. To accelerate progress in this area, an international consortium of researchers and clinicians, the Learning Disabilities Network (LeaDNet), was established in 2006. Initially, LeaDNet focused on neurofibromatosis type 1 (NF1), a common single gene disorder with a frequency of 1:3,000. Although NF1 is best recognized as an inherited tumor predisposition syndrome, learning, cognitive, and neurobehavioral deficits account for significant morbidity in this condition and can have a profound impact on the quality of life of affected individuals. Recently, there have been groundbreaking advances in our understanding of the molecular, cellular, and neural systems underpinnings of NF1-associated learning deficits in animal models, which precipitated clinical trials using a molecularly targeted treatment for these deficits. However, much remains to be learned about the spectrum of cognitive, neurological, and psychiatric phenotypes associated with the NF1 clinical syndrome. In addition, there is a pressing need to accelerate the identification of specific clinical targets and treatments for these phenotypes. The successes with NF1 have allowed LeaDNet investigators to broaden their initial focus to other genetic disorders characterized by learning disabilities and cognitive deficits including other RASopathies (caused by changes in the Ras signaling pathway). The ultimate mission of LeaDNet is to leverage an international translational consortium of clinicians and neuroscientists to integrate bench-to-bedside knowledge across a broad range of cognitive genetic disorders, with the goal of accelerating the development of rational and biologically based treatments.

Pediatric assessment and management of concussions.

Abstract: Concussions and mild traumatic brain injuries have become more widely recognized and understood during the past 5 to 10 years. Earlier and more active evaluation and management of this brain injury is necessary to reduce risk to the developing child and adolescent. Pediatricians play a central role in the evaluation and management of concussions and should develop a working understanding of the injury and its clinical manifestations. An individualized approach to evaluation and management by the pediatrician requires the development of a skillset to define the characteristics of the injury, conduct a full assessment of post-concussion symptoms, and define any risk history that may modify recovery. This evaluation forms the basis of concussion treatment, which involves the active management of the child’s daily routines at home, school learning and performance, and sports/recreational activities. The Acute Concussion Evaluation (ACE) and ACE Care Plan, published in the CDC’s “Heads Up: Concussion in Your Practice,” are presented as a set of tools that can assist the pediatrician in this endeavor.

Low frequency oscillations of response time explain parent ratings of inattention and hyperactivity/impulsivity

Abstract: Greater intra-subject variability (ISV) in response time is a heritable endophenotype of attention-deficit/hyperactivity disorder (ADHD). Spontaneous low frequency oscillations (LFO: 0.01–0.1 Hz) observed in brain functional magnetic resonance signals might account for such behavioral variability. Recently, we demonstrated that ISV in response time (RT) explained ratings of ADHD symptoms. Building on this finding, here we hypothesized that LFO in RT time series would explain these ratings, both independently and in addition to RT coefficient of variation (CV). To measure RT LFO, we applied Morlet wavelet transform to the previously collected RT data. Our community sample consisted of 98 children (including 66 boys, mean age 9.9 ± 1.4 years), who completed four computer Tasks of Executive Control. Conners’ Parent Rating Scale ratings were obtained. RT LFO of three tasks significantly explained ratings of inattention, hyperactivity and three global Conners’ subscales. In addition, RT LFO during two tasks that included an inhibitory component increased the proportions of variance explained in subscales of both inattention and hyperactivity/impulsivity, beyond the effects of RT-CV. Three specific low frequency bands (Slow-5: 0.01–0.027 Hz; Slow-4: 0.027–0.073 Hz; Slow-3: 0.073–0.20 Hz) were strongly related to the ADHD scales. We conclude that RT LFO predict dimensional ratings of ADHD symptoms both independently and in addition to RTCV. Results suggest that frequency analyses are a suitable methodology to link behavioral responses to putative underlying physiological processes.

Developmental Considerations in Pediatric Concussion Evaluation and Management

Abstract: Evaluation and management of concussion in the child and adolescent requires a developmentally appropriate clinical model, emphasizing key factors relevant to the injury manifestation and needs of the child. This chapter presents a model for clinical evaluation and management of concussion in children and adolescents at the acute and postacute stages. Multiple methods and informants are incorporated with the evaluation guided by the specific goals and timing of the service in relation to the injury. Appropriate assessment and intervention tools are discussed for each stage, as well as reasons for referral for additional levels of care. The fundamental components of a pediatric concussion evaluation include the following: definition of injury characteristics; history of premorbid and postinjury risk factors; assessment of current neurocognitive functioning, postconcussion symptoms, and balance; and examination of social–emotional functioning. Different disciplines contribute to the evaluation and management of pediatric concussion. The concept of the concussion generalist and specialist service is introduced with suggested requisite training, skills, and knowledge to evaluate and manage the full range of complexity of pediatric concussion.