H
Hélène Blons
Researcher at University of Paris
Publications - 183
Citations - 8070
Hélène Blons is an academic researcher from University of Paris. The author has contributed to research in topics: KRAS & Cancer. The author has an hindex of 46, co-authored 161 publications receiving 6698 citations. Previous affiliations of Hélène Blons include French Institute of Health and Medical Research & Sorbonne.
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Journal ArticleDOI
Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)
Fabrice Barlesi,Julien Mazieres,Jean-Philippe Merlio,Didier Debieuvre,Jean Mosser,Hervé Lena,L'Houcine Ouafik,Benjamin Besse,Isabelle Rouquette,Virginie Westeel,Fabienne Escande,Isabelle Monnet,Antoinette Lemoine,Remi Veillon,Hélène Blons,Clarisse Audigier-Valette,Pierre-Paul Bringuier,R. Lamy,Michèle Beau-Faller,Jean-Louis Pujol,Jean-Christophe Sabourin,Frédérique Penault-Llorca,Marc G. Denis,Sylvie Lantuejoul,Franck Morin,Quân Tran,P. Missy,Alexandra Langlais,Bernard Milleron,Jacques Cadranel,Jean-Charles Soria,Gérard Zalcman +31 more
TL;DR: The frequency of genetic alterations, acceptable turnaround times in obtaining analysis results, and the clinical advantage provided by detection of a genetic alteration suggest that this nationwide molecular profiling of patients with advanced NSCLC provides a clinical benefit.
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Lung Cancer That Harbors an HER2 Mutation: Epidemiologic Characteristics and Therapeutic Perspectives
Julien Mazieres,Solange Peters,Benoit Lepage,Alexis B. Cortot,Fabrice Barlesi,Michèle Beau-Faller,Benjamin Besse,Hélène Blons,Audrey Mansuet-Lupo,Thierry Urban,Denis Moro-Sibilot,Eric Dansin,Christos Chouaid,Marie Wislez,Joachim Diebold,Enriqueta Felip,Isabelle Rouquette,Julie Milia,Oliver Gautschi +18 more
TL;DR: This study, the largest to date dedicated to Her2-mutated NSCLC, reinforces the importance of screening for HER2 mutations in lung adenocarcinomas and suggests the potential efficacy of HER2-targeted drugs in this population.
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Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients
Valérie Taly,Deniz Pekin,Deniz Pekin,Leonor Benhaim,Steve K. Kotsopoulos,Delphine Le Corre,Xinyu Li,Ivan Atochin,Darren R. Link,Andrew D. Griffiths,Andrew D. Griffiths,Karine Pallier,Hélène Blons,Olivier Bouché,Bruno Landi,J. Brian Hutchison,Pierre Laurent-Puig +16 more
TL;DR: Clinical utility of multiplex dPCR to screen for multiple mutations simultaneously with a sensitivity sufficient to detect mutations in circulating DNA obtained by noninvasive blood collection is demonstrated.
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Transplantation of Human Embryonic Stem Cell–Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction
Philippe Menasché,Valérie Vanneaux,Albert Hagège,Alain Bel,Bernard Cholley,Alexandre Parouchev,Isabelle Cacciapuoti,Reem Al-Daccak,Nadine Benhamouda,Hélène Blons,Onnik Agbulut,Lucie Tosca,Jean-Hugues Trouvin,Jean-Roch Fabreguettes,Valérie Bellamy,Dominique Charron,Eric Tartour,Gérard Tachdjian,Michel Desnos,Jérôme Larghero +19 more
TL;DR: This trial demonstrates the technical feasibility of producing clinical-grade hESC-derived cardiovascular progenitors and supports their short- and medium-term safety, thereby setting the grounds for adequately powered efficacy studies.
Journal ArticleDOI
Detection of free‐circulating tumor‐associated DNA in plasma of colorectal cancer patients and its association with prognosis
Thierry Lecomte,Anne Berger,Franck Zinzindohoué,Stephanie Micard,Bruno Landi,Hélène Blons,Philippe Beaune,Paul-Henri Cugnenc,Pierre Laurent-Puig +8 more
TL;DR: The presence of free‐circulating tumor‐associated DNA in plasma seems to be a relevant prognostic marker for patients with colorectal cancer and may be used to identify patients with a high risk of recurrence.