G
Gerard Terradas
Researcher at University of California, San Diego
Publications - 15
Citations - 435
Gerard Terradas is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Aedes aegypti & Dengue virus. The author has an hindex of 8, co-authored 11 publications receiving 248 citations. Previous affiliations of Gerard Terradas include Monash University & Autonomous University of Barcelona.
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Journal ArticleDOI
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi.
Adriana Adolfi,Adriana Adolfi,Valentino M. Gantz,Nijole Jasinskiene,H. K. Lee,Kristy S. Hwang,Gerard Terradas,Emily A. Bulger,Arunachalam Ramaiah,Jared B. Bennett,J. J. Emerson,John M. Marshall,Ethan Bier,Anthony A. James +13 more
TL;DR: A recoded gene-drive rescue system for population modification of the malaria vector, Anopheles stephensi, that relieves the load in females caused by integration of the drive into the kynurenine hydroxylase gene by rescuing its function is developed.
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The RNAi pathway plays a small part in Wolbachia-mediated blocking of dengue virus in mosquito cells.
TL;DR: It is shown that while Wolbachia infection induces genes in the Toll, JAK/STAT and RNAi pathways, only reduced expression of RNAi leads to a rebound of dengue virus loads in Wolbachio-infected cells, demonstrating that blocking must be dependent on other factors in addition to the expression ofRNAi.
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Wolbachia-mediated virus blocking in the mosquito vector Aedes aegypti
TL;DR: Current hypotheses in the field for the mechanistic basis of pathogen blocking and the evidence from mosquitoes and related insects are discussed and evaluated.
Journal ArticleDOI
Inherently confinable split-drive systems in Drosophila
Gerard Terradas,Anna Buchman,Jared B. Bennett,Isaiah Shriner,John M. Marshall,Omar S. Akbari,Ethan Bier +6 more
TL;DR: In this paper, split gene-drive (sGD) systems were tested in Drosophila melanogaster that are inserted into essential genes required for viability (rab5, rab11, prosalpha2) or fertility (spo11).
Journal ArticleDOI
A Role for the Insulin Receptor in the Suppression of Dengue Virus and Zika Virus in Wolbachia-Infected Mosquito Cells.
Gholamreza Haqshenas,Gerard Terradas,Prasad N. Paradkar,Jean-Bernard Duchemin,Elizabeth A. McGraw,Elizabeth A. McGraw,Christian Doerig +6 more
TL;DR: Wolbachia-mediated downregulation of insulin receptor kinase activity is identified as a mechanism contributing to the blocking of super-infection by arboviruses.