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Inna Belfer
Researcher at National Institutes of Health
Publications - 40
Citations - 3575
Inna Belfer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chronic pain & Haplotype. The author has an hindex of 21, co-authored 40 publications receiving 3337 citations. Previous affiliations of Inna Belfer include Center for Drug Evaluation and Research & University of Pennsylvania.
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Journal ArticleDOI
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko,Gary D. Slade,Andrea G. Nackley,Konakporn Bhalang,Asgeir Sigurdsson,Inna Belfer,David Goldman,Ke Xu,Svetlana A. Shabalina,Dmitry A. Shagin,Mitchell B. Max,Sergei S. Makarov,William Maixner +12 more
TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
Journal ArticleDOI
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Irmgard Tegeder,Michael Costigan,Robert S. Griffin,Andrea Abele,Inna Belfer,Helmut Schmidt,Corina Ehnert,Jemiel Nejim,Jemiel Nejim,Claudiu Marian,Joachim Scholz,Tianxia Wu,Andrew Allchorne,Luda Diatchenko,Alexander M. Binshtok,David Goldman,Jan Adolph,Swetha Sama,Steven J. Atlas,William A. Carlezon,Aram Parsegian,Jörn Lötsch,Roger B. Fillingim,William Maixner,Gerd Geisslinger,Mitchell B. Max,Clifford J. Woolf +26 more
TL;DR: It is reported that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain.
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Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
Luda Diatchenko,Andrea G. Nackley,Gary D. Slade,Kanokporn Bhalang,Inna Belfer,Mitchell B. Max,David Goldman,William Maixner +7 more
TL;DR: A mechanism whereby these two genetic polymorphisms differentially affect pain perception is proposed, which suggests that other SNPs of the COMT haplotype exert a greater influence on resting nociceptive sensitivity.
Journal ArticleDOI
Influence of psychological factors on risk of temporomandibular disorders
Gary D. Slade,Luda Diatchenko,Kanokporn Bhalang,Asgeir Sigurdsson,Roger B. Fillingim,Inna Belfer,Mitchell B. Max,David Goldman,William Maixner +8 more
TL;DR: Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05), but the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype.
Journal ArticleDOI
Three major haplotypes of the β2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder†
Luda Diatchenko,Amy D. Anderson,Gary D. Slade,Roger B. Fillingim,Svetlana A. Shabalina,Tomas J. Higgins,Swetha Sama,Inna Belfer,David Goldman,Mitchell B. Max,Bruce S. Weir,William Maixner +11 more
TL;DR: The data suggest that either positive or negative imbalances in ADRB2 function increase the vulnerability to chronic pain conditions such as TMD through different etiological pathways that imply the need for tailored treatment options.