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William Maixner
Researcher at Duke University
Publications - 337
Citations - 28736
William Maixner is an academic researcher from Duke University. The author has contributed to research in topics: Chronic pain & Orofacial pain. The author has an hindex of 82, co-authored 336 publications receiving 25006 citations. Previous affiliations of William Maixner include Royal Children's Hospital & American Pain Society.
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Journal ArticleDOI
Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†
Eric L. Schiffman,Richard Ohrbach,Edmond L. Truelove,John O Look,Gary C. Anderson,Jean-Paul Goulet,Thomas List,Peter Svensson,Peter Svensson,Yoly Gonzalez,Frank Lobbezoo,Ambra Michelotti,Sharon L. Brooks,Werner Ceusters,Mark Drangsholt,Dominik A Ettlin,Charly Gaul,Louis J. Goldberg,Jennifer A. Haythornthwaite,Lars Hollender,Rigmor Jensen,Mike T. John,Antoon De Laat,Reny de Leeuw,William Maixner,Marylee J van der Meulen,Greg M. Murray,Donald R. Nixdorf,Donald R. Nixdorf,Donald R. Nixdorf,Sandro Palla,Arne Petersson,Paul Pionchon,Barry Smith,Corine M. Visscher,Joanna Zakrzewska,Samuel F. Dworkin +36 more
TL;DR: The newly recommended evidence-based new DC/TMD protocol is appropriate for use in both clinical and research settings and includes both a valid screener for detecting any pain-related TMD as well as valid diagnostic criteria for differentiating the most common pain- related TMD.
Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: Recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain
Eric L. Schiffman,Gary C. Anderson,Jean-Paul Goulet,Peter Svensson,Frank Lobbezoo,Ambra Michelotti,Sharon L. Brooks,Werner Ceusters,Dominik A Ettlin,Louis J. Goldberg,Jennifer A. Haythornthwaite,Lars Hollender,Rigmor Jensen,Mike T. John,William Maixner,Marylee J van der Meulen,Greg M. Murray,Donald R. Nixdorf,Sandro Palla,Paul Pionchon,Barry Smith,Corine M. Visscher,Joanna M Zakrzewska,Samuel F. Dworkin +23 more
TL;DR: In this article, the authors proposed a new RDC/TMD Axis I and Axis II diagnostic algorithms for temporomandibular joint (TMJ) intra-articular disorder.
Journal ArticleDOI
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko,Gary D. Slade,Andrea G. Nackley,Konakporn Bhalang,Asgeir Sigurdsson,Inna Belfer,David Goldman,Ke Xu,Svetlana A. Shabalina,Dmitry A. Shagin,Mitchell B. Max,Sergei S. Makarov,William Maixner +12 more
TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
Journal ArticleDOI
Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure
Andrea G. Nackley,Svetlana A. Shabalina,Inna E. Tchivileva,K. Satterfield,O. Korchynskyi,Sergei S. Makarov,William Maixner,Luda Diatchenko +7 more
TL;DR: The major COMT haplotypes varied with respect to messenger RNA local stem-loop structures, such that the most stable structure was associated with the lowest protein levels and enzymatic activity.
Journal ArticleDOI
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
TL;DR: Neuroinflammation drives widespread chronic pain via central sensitization and sex-dependent glial/immune signaling in chronic pain and new therapeutic approaches that control neuroinflammation for the resolution of chronic pain are discussed.