T
Tianxia Wu
Researcher at National Institutes of Health
Publications - 109
Citations - 5584
Tianxia Wu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Multiple sclerosis. The author has an hindex of 35, co-authored 97 publications receiving 4525 citations. Previous affiliations of Tianxia Wu include United States Department of Agriculture.
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Journal ArticleDOI
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Irmgard Tegeder,Michael Costigan,Robert S. Griffin,Andrea Abele,Inna Belfer,Helmut Schmidt,Corina Ehnert,Jemiel Nejim,Jemiel Nejim,Claudiu Marian,Joachim Scholz,Tianxia Wu,Andrew Allchorne,Luda Diatchenko,Alexander M. Binshtok,David Goldman,Jan Adolph,Swetha Sama,Steven J. Atlas,William A. Carlezon,Aram Parsegian,Jörn Lötsch,Roger B. Fillingim,William Maixner,Gerd Geisslinger,Mitchell B. Max,Clifford J. Woolf +26 more
TL;DR: It is reported that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain.
Journal Article
Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis--United States, 1988-1994 and 1999-2002.
Eugenio D. Beltrán-Aguilar,Laurie K. Barker,Maria Teresa Canto,Bruce A. Dye,Barbara F. Gooch,Susan O. Griffin,Jeffrey Hyman,Freder Jaramillo,Albert Kingman,Ruth Nowjack-Raymer,Robert H. Selwitz,Tianxia Wu +11 more
TL;DR: For example, the first CDC Surveillance Summary that addresses these conditions and practices was published in 1999-2002 as mentioned in this paper, which indicated that the dental caries status of permanent teeth has improved since the 1988-1994 survey.
Journal ArticleDOI
Pain perception is altered by a nucleotide polymorphism in SCN9A
Frank Reimann,James J. Cox,Inna Belfer,Luda Diatchenko,Dmitri V. Zaykin,Duncan McHale,Joost P.H. Drenth,Feng Dai,Jerry Wheeler,Frances A. Sanders,Linda S. Wood,Tianxia Wu,Jaro Karppinen,Lone Nikolajsen,Minna Männikkö,Mitchell B. Max,Carly Kiselycznyk,Minakshi Poddar,Rene H. M. te Morsche,Shad B. Smith,Dustin G. Gibson,Anthi Kelempisioti,William Maixner,Fiona M. Gribble,C. Geoffrey Woods +24 more
TL;DR: It is concluded that individuals experience differing amounts of pain, per nociceptive stimulus, on the basis of their SCN9A rs6746030 genotype.
Journal ArticleDOI
Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo.
Martina Absinta,Pascal Sati,Federica Masuzzo,Govind Nair,Varun Sethi,Hadar Kolb,Joan Ohayon,Tianxia Wu,Irene Cortese,Daniel S. Reich +9 more
TL;DR: Investigation of chronic rim lesions on 7-T or 3-T susceptibility-based brain MRI in 192 patients with MS and the association of rim counts with clinical disability and brain volume changes prompted the planning of MRI-based clinical trials aimed at treating perilesional chronic inflammation in MS.
Journal ArticleDOI
Multiple chronic pain states are associated with a common amino acid–changing allele in KCNS1
Michael Costigan,Inna Belfer,Robert S. Griffin,Feng Dai,Lee Barrett,Giovanni Coppola,Tianxia Wu,Carly Kiselycznyk,Minakshi Poddar,Yan Lu,Luda Diatchenko,Shad B. Smith,Enrique J. Cobos,Dmitri V. Zaykin,Andrew Allchorne,Pei Hong Shen,Lone Nikolajsen,Jaro Karppinen,Minna Männikkö,Anthi Kelempisioti,David Goldman,William Maixner,Daniel H. Geschwind,Mitchell B. Max,Ze'ev Seltzer,Clifford J. Woolf +25 more
TL;DR: The KCNS1 allele rs734784, involved in neuronal excitability, is presented as one of the first prognostic indicators of chronic pain risk and could help define those individuals prone to a transition to persistent pain, and thus requiring therapeutic strategies or lifestyle changes that minimize nerve injury.