Journal ArticleDOI
Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System
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TLDR
It is suggested that multidrug transporters are essential parts of an innate defense system, the "chemoimmunity" network, which has a number of features reminiscent of classical immunology.Abstract:
In this review we give an overview of the physiological functions of a group of ATP binding cassette (ABC) transporter proteins, which were discovered, and still referred to, as multidrug resistanc...read more
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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
TL;DR: The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
Journal ArticleDOI
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Andrea Cossarizza,Hyun-Dong Chang,Andreas Radbruch,Andreas Acs,Dieter Adam,Sabine Adam-Klages,William W. Agace,William W. Agace,Nima Aghaeepour,Mübeccel Akdis,Matthieu Allez,Larissa Nogueira Almeida,Giorgia Alvisi,Graham Anderson,Immanuel Andrä,Francesco Annunziato,Achille Anselmo,Petra Bacher,Cosima T. Baldari,Sudipto Bari,Vincenzo Barnaba,Vincenzo Barnaba,Joana Barros-Martins,Luca Battistini,Wolfgang Bauer,Sabine Baumgart,Nicole Baumgarth,Dirk Baumjohann,Bianka Baying,Mary Bebawy,Burkhard Becher,Wolfgang Beisker,Vladimir Benes,Rudi Beyaert,Alfonso Blanco,Dominic A. Boardman,Christian Bogdan,Jessica G. Borger,Giovanna Borsellino,Philip E. Boulais,Jolene Bradford,Dirk Brenner,Dirk Brenner,Ryan R. Brinkman,Anna E. S. Brooks,Dirk H. Busch,Martin Büscher,Timothy P. Bushnell,Federica Calzetti,Garth Cameron,Ilenia Cammarata,Xuetao Cao,Susanna Cardell,Stefano Casola,Marco A. Cassatella,Andrea Cavani,Antonio Celada,Lucienne Chatenoud,Pratip K. Chattopadhyay,Sue Chow,Eleni Christakou,Eleni Christakou,Luka Cicin-Sain,Mario Clerici,Federico Colombo,Laura Cook,Anne Cooke,Andrea M. Cooper,Alexandra J. Corbett,Antonio Cosma,Lorenzo Cosmi,Pierre Coulie,Ana Cumano,Ljiljana Cvetkovic,Van Duc Dang,Chantip Dang-Heine,Martin S. Davey,Derek Davies,Sara De Biasi,Genny Del Zotto,Gelo Victoriano Dela Cruz,Michael Delacher,Silvia Della Bella,Paolo Dellabona,Günnur Deniz,Mark C. Dessing,James P. Di Santo,Andreas Diefenbach,Francesco Dieli,Andreas Dolf,Thomas Dörner,Regine J. Dress,Diana Dudziak,Michael L. Dustin,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Friederike Ebner,Sidonia B G Eckle,Matthias Edinger,Pascale Eede,Götz R. A. Ehrhardt,Marcus Eich,Pablo Engel,Britta Engelhardt,Anna Erdei,Charlotte Esser,Bart Everts,Maximilien Evrard,Christine S. Falk,Todd A. Fehniger,Mar Felipo-Benavent,Helen Ferry,Markus Feuerer,Andrew Filby,Kata Filkor,Simon Fillatreau,Marie Follo,Irmgard Förster,John Bellamy Foster,Gemma A. Foulds,Britta Frehse,Paul S. Frenette,Stefan Frischbutter,Wolfgang Fritzsche,David W. Galbraith,David W. Galbraith,Anastasia Gangaev,Natalio Garbi,Brice Gaudilliere,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Jens Geginat,Wilhelm Gerner,Nicholas A Gherardin,Kamran Ghoreschi,Lara Gibellini,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Keisuke Goda,Keisuke Goda,Keisuke Goda,Dale I. Godfrey,Christoph Goettlinger,José M. González-Navajas,Carl S. Goodyear,Andrea Gori,Jane L. Grogan,Daryl Grummitt,Andreas Grützkau,Claudia Haftmann,Jonas Hahn,Hamida Hammad,Günter J. Hämmerling,Leo Hansmann,Göran K. Hansson,Christopher M. Harpur,Susanne Hartmann,Andrea Hauser,Anja E. Hauser,David L. Haviland,David W. Hedley,Daniela C. Hernández,Guadalupe Herrera,Martin Herrmann,Christoph Hess,Christoph Hess,Thomas Höfer,Petra Hoffmann,Kristin A. Hogquist,Tristan Holland,Thomas Höllt,Thomas Höllt,Rikard Holmdahl,Pleun Hombrink,Jessica P. Houston,Bimba F. Hoyer,Bo Huang,Fang-Ping Huang,Johanna Huber,Jochen Huehn,Michael Hundemer,Christopher A. Hunter,William Hwang,William Hwang,Anna Iannone,Florian Ingelfinger,Sabine Ivison,Hans-Martin Jäck,Peter K. Jani,Beatriz Jávega,Stipan Jonjić,Toralf Kaiser,Tomas Kalina,Thomas Kamradt,Stefan H. E. Kaufmann,Baerbel Keller,Steven L. C. Ketelaars,Ahad Khalilnezhad,Ahad Khalilnezhad,Srijit Khan,Jan Kisielow,Paul Klenerman,Jasmin Knopf,Hui-Fern Koay,Katja Kobow,Jay K. Kolls,Wan Ting Kong,Manfred Kopf,Thomas Korn,Katharina Kriegsmann,Hendy Kristyanto,Thomas Kroneis,Andreas Krueger,J. Kühne,Christian Kukat,Désirée Kunkel,Heike Kunze-Schumacher,Tomohiro Kurosaki,Christian Kurts,Pia Kvistborg,Immanuel Kwok,Immanuel Kwok,Jonathan J M Landry,Olivier Lantz,Paola Lanuti,Francesca LaRosa,Agnès Lehuen,Salomé LeibundGut-Landmann,Michael D. Leipold,Leslie Y. T. Leung,Megan K. Levings,Andreia C. Lino,Francesco Liotta,Virginia Litwin,Yanling Liu,Hans-Gustaf Ljunggren,Michael Lohoff,Giovanna Lombardi,Lilly Lopez,Miguel López-Botet,Amy E. Lovett-Racke,Erik Lubberts,Hervé Luche,Burkhard Ludewig,Enrico Lugli,Sebastian Lunemann,Holden T. Maecker,Laura Maggi,Orla Maguire,Florian Mair,Kerstin H. Mair,Alberto Mantovani,Rudolf A. Manz,Aaron J. Marshall,Alicia Martínez-Romero,Gloria Martrus,Ivana Marventano,Wlodzimierz Maslinski,Giuseppe Matarese,Anna Vittoria Mattioli,Christian Maueröder,Christian Maueröder,Alessio Mazzoni,James McCluskey,Mairi McGrath,Helen M. McGuire,Iain B. McInnes,Henrik E. Mei,Fritz Melchers,Susanne Melzer,Dirk Mielenz,Stephen D. Miller,Kingston H. G. Mills,Hans Minderman,Jenny Mjösberg,Jenny Mjösberg,Jonni S. Moore,Barry Moran,Lorenzo Moretta,Tim R. Mosmann,Susann Müller,Gabriele Multhoff,Luis E. Muñoz,Christian Münz,Toshinori Nakayama,Milena Nasi,Katrin Neumann,Lai Guan Ng,Antonia Niedobitek,Sussan Nourshargh,Gabriel Núñez,José-Enrique O'Connor,A Ochel,Anna E. Oja,Diana Ordonez,Alberto Orfao,Eva Orlowski-Oliver,Wenjun Ouyang,Annette Oxenius,Raghavendra Palankar,Isabel Panse,Kovit Pattanapanyasat,Malte Paulsen,Dinko Pavlinic,Livius Penter,Pärt Peterson,Christian Peth,Jordi Petriz,Federica Piancone,Winfried F. Pickl,Silvia Piconese,Marcello Pinti,A. Graham Pockley,Malgorzata J. Podolska,Zhiyong Poon,Katharina Pracht,Immo Prinz,Carlo Pucillo,Sally A. Quataert,Linda Quatrini,Kylie M. Quinn,Kylie M. Quinn,Helena Radbruch,Tim R. Radstake,Susann Rahmig,Hans-Peter Rahn,Bartek Rajwa,Gevitha Ravichandran,Yotam Raz,Jonathan Rebhahn,Diether J. Recktenwald,Dorothea Reimer,Caetano Reis e Sousa,Ester B. M. Remmerswaal,Lisa Richter,Laura G. Rico,Andy Riddell,Aja M. Rieger,J. Paul Robinson,Chiara Romagnani,Anna Rubartelli,Jürgen Ruland,Armin Saalmüller,Yvan Saeys,Takashi Saito,Shimon Sakaguchi,Francisco Sala-de-Oyanguren,Yvonne Samstag,Sharon Sanderson,Inga Sandrock,Angela Santoni,Ramon Bellmas Sanz,Marina Saresella,Catherine Sautès-Fridman,Birgit Sawitzki,Linda Schadt,Alexander Scheffold,Hans Scherer,Matthias Schiemann,Frank A. Schildberg,Esther Schimisky,Andreas Schlitzer,Josephine Schlosser,S Schmid,Steffen Schmitt,Kilian Schober,Daniel Schraivogel,Wolfgang Schuh,Thomas Schüler,Reiner Schulte,Axel Schulz,Sebastian R. Schulz,Cristiano Scottà,Daniel Scott-Algara,David P. Sester,T. Vincent Shankey,Bruno Silva-Santos,Anna Katharina Simon,Katarzyna M. Sitnik,Silvano Sozzani,Daniel E. Speiser,Josef Spidlen,Anders Ståhlberg,Alan M. Stall,Natalie Stanley,Regina Stark,Christina Stehle,Tobit Steinmetz,Hannes Stockinger,Yousuke Takahama,Kiyoshi Takeda,Leonard Tan,Leonard Tan,Attila Tárnok,Attila Tárnok,Attila Tárnok,Gisa Tiegs,Gergely Toldi,Julia Tornack,Elisabetta Traggiai,Mohamed Trebak,Timothy Tree,Timothy Tree,Joe Trotter,John Trowsdale,Maria Tsoumakidou,Henning Ulrich,Sophia Urbanczyk,Willem van de Veen,Maries van den Broek,Edwin van der Pol,Sofie Van Gassen,Gert Van Isterdael,René A. W. van Lier,Marc Veldhoen,Salvador Vento-Asturias,Paulo Vieira,David Voehringer,Hans-Dieter Volk,Anouk von Borstel,Konrad von Volkmann,Ari Waisman,Rachael C. Walker,Paul K. Wallace,Sa A. Wang,Xin M. Wang,Michael D. Ward,Kirsten A. Ward-Hartstonge,Klaus Warnatz,Gary Warnes,Sarah Warth,Claudia Waskow,Claudia Waskow,James V. Watson,Carsten Watzl,Leonie Wegener,Thomas Weisenburger,Annika Wiedemann,Jürgen Wienands,Anneke Wilharm,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Gerald Willimsky,James B. Wing,Rieke Winkelmann,Thomas Winkler,Oliver F. Wirz,Alicia Wong,Peter Wurst,Jennie H M Yang,Jennie H M Yang,Juhao Yang,Maria Yazdanbakhsh,Liping Yu,Alice Yue,Hanlin Zhang,Yi Zhao,Susanne Ziegler,Christina E. Zielinski,Jakob Zimmermann,Arturo Zychlinsky +462 more
TL;DR: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community providing the theory and key practical aspects offlow cytometry enabling immunologists to avoid the common errors that often undermine immunological data.
Journal ArticleDOI
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment.
Kyung-Jin Jang,Ali Poyan Mehr,Ali Poyan Mehr,Geraldine A. Hamilton,Lori McPartlin,Seyoon Chung,Seyoon Chung,Kahp-Yang Suh,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +10 more
TL;DR: A microfluidic device lined by living human kidney epithelial cells exposed to fluidic flow that mimics key functions of the human kidney proximal tubule is described, suggesting that it might serve as a useful tool for evaluating human-relevant renal toxicity in preclinical safety studies.
Journal ArticleDOI
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
Ilka Maschmeyer,Alexandra Lorenz,Katharina Schimek,Tobias Hasenberg,Anja Patricia Ramme,Juliane Hübner,Marcus Lindner,Christopher Drewell,Sophie Bauer,Alexander Thomas,Naomia Sisoli Sambo,Frank Sonntag,Roland Lauster,Uwe Marx +13 more
TL;DR: This study is the first approach to establish a system for in vitro microfluidic ADME profiling and repeated dose systemic toxicity testing of drug candidates over 28 days in co-culture, and assures near to physiological fluid-to-tissue ratios.
Journal ArticleDOI
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade.
TL;DR: The development of new compounds and the re-evaluation of compounds originally designed for other targets as transport inhibitors of ATP-dependent drug efflux pumps are summarized.
References
More filters
Journal ArticleDOI
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
Journal ArticleDOI
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Michael M. Gottesman,Ira Pastan +1 more
Journal ArticleDOI
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.
TL;DR: Observations on the molecular basis of pleiotropic drug resistance are interpreted in terms of a model wherein certain surface glycoproteins control drug permeation by modulating the properties of hydrophobic membrane regions.
Journal ArticleDOI
Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
Journal ArticleDOI
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Sheng Zhou,John D. Schuetz,Kevin D. Bunting,Anne-Marie Colapietro,Janardhan Sampath,John J. Morris,Irina Lagutina,Gerard Grosveld,Mitsujiro Osawa,Hiromitsu Nakauchi,Brian P. Sorrentino +10 more
TL;DR: Results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources.