G
Gerhart U. Ryffel
Researcher at University of Bern
Publications - 76
Citations - 4693
Gerhart U. Ryffel is an academic researcher from University of Bern. The author has contributed to research in topics: Xenopus & Gene. The author has an hindex of 36, co-authored 76 publications receiving 4609 citations.
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An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells.
TL;DR: The fact that the ERE of a frog gene functions in human cells demonstrates that signals and factors involved in the control have been conserved during evolution.
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A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor
TL;DR: This work has defined the 13 bp palindrome GGTCACAGTGACC as a minimal functional estrogen responsive element (ERE), which binds estrogen receptor preferentially in vitro and point mutations within the ERE decrease its affinity for the estrogen receptor and result in a complete loss of estrogen inducibility.
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Vitellogenesis and the Vitellogenin Gene Family
TL;DR: Rapid evolutionary change involving rearrangements and the presence of repeated DNA suggests that the bulk of the sequences within introns may not have any specific function.
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Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.
TL;DR: Cotransfection experiments in C2 and HeLa cells showed that HNF4 gamma is significantly less active than HNF 4 alpha 2 and that the novel H NF4 alpha splice variant HNF3 alpha 4 has no detectable transactivation potential, suggesting that the differential expression of distinct HNF5 proteins may play a key role in the differential transcriptional regulation of HNF2-dependent genes.
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Vitellogenin in Xenopus laevis is encoded in a small family of genes
TL;DR: It is suggested that vitellogenin is encoded by a small family of related genes in Xenopus, as well as two main groups of sequences which differ from each other in approximately 20% of their nucleotides.