Gerrit Koopman

TL;DR: The results indicate that the phase in apoptosis that is characterized by chromatin condensation coincides with phosphatidylserine exposure, which precedes membrane damage that might lead to release from the cells of enzymes that are harmful to the surrounding tissues.

TL;DR: The reaction pattern of various antibodies indicates that these CD44 variants contain the domain encoded by exon v6, which is part of the variant that in the rat confers metastatic capability and it is interesting that overexpression of v6 was also found in several aggressive, but not low-grade, non- Hodgkin's lymphomas.

TL;DR: The data strongly suggest that adhesion of B cells via the LFA-1 (CD11a/CD18)-ICAM-1(CD54) pathway and VLA-4 (CD49d)-VCAM- 1 (CD106) pathway contributes to B cell selection.

TL;DR: It is established that both the LFA-1/ICAM-1 and VLA-4/VCam-1 adhesion pathways are involved in FDC-B lymphocyte binding, and therefore, these pathways might be essential in affinity selection of B cells and in the formation of B memory cells.

TL;DR: It is demonstrated that triggering of CD44 on T lymphocytes by anti-CD44 mAb promotes cell adhesion, suggesting that the activation of the LFA-1 pathway via CD44 involves protein kinase C activation and requires an intact cytoskeleton.