F
F. M. Van Den Berg
Researcher at University of Amsterdam
Publications - 36
Citations - 3142
F. M. Van Den Berg is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Carcinogenesis & Immunohistochemistry. The author has an hindex of 23, co-authored 36 publications receiving 3084 citations. Previous affiliations of F. M. Van Den Berg include Johns Hopkins University.
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Journal Article
Expression of CD44 Variant Proteins in Human Colorectal Cancer Is Related to Tumor Progression
V. J. M. Wielenga,K H Heider,G. J. A. Offerhaus,Günther R. Adolf,F. M. Van Den Berg,Helmut Ponta,Peter Herrlich,S. T. Pals +7 more
TL;DR: The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans.
Journal ArticleDOI
A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.
TL;DR: The finding that metastasis-related variants are already expressed at a relatively early stage in colorectal carcinogenesis and tumor progression, i.e., in adenomatous polyps, suggests the existence of a yet unknown selective advantage linked to CD44 variant expression.
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Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44
Gerrit Koopman,K.-H. Heider,E. Horst,G. R. Adolf,F. M. Van Den Berg,H Ponta,P. Herrlich,Steven T. Pals +7 more
TL;DR: The reaction pattern of various antibodies indicates that these CD44 variants contain the domain encoded by exon v6, which is part of the variant that in the rat confers metastatic capability and it is interesting that overexpression of v6 was also found in several aggressive, but not low-grade, non- Hodgkin's lymphomas.
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The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls
TL;DR: The intestinal mucus in IBD patients is less protective against the endogenous microflora than in controls, resulting in increased association of luminal bacteria with the mucus layer.
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Overexpression of p53 Protein in Adenocarcinoma of the Pancreas
Joseph A. DiGiuseppe,Ralph H. Hruban,Steven N. Goodman,M. Polak,F. M. Van Den Berg,David C. Allison,John L. Cameron,G. J. A. Offerhaus +7 more
TL;DR: It is concluded that overexpression of the p53 protein occurs frequently in invasive adenocarcinomas of the pancreas and in some in situ carcinomas, as well.