G
Giacomo Salvadore
Researcher at Janssen Pharmaceutica
Publications - 27
Citations - 1231
Giacomo Salvadore is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Sirukumab & Dementia. The author has an hindex of 11, co-authored 27 publications receiving 866 citations. Previous affiliations of Giacomo Salvadore include ACADIA Pharmaceuticals Inc. & Johnson & Johnson.
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Journal ArticleDOI
Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis
Toby Wise,Joaquim Radua,Joaquim Radua,Esther Via,Narcís Cardoner,Osamu Abe,Tracey M. Adams,Francesco Amico,Yuqi Cheng,James H. Cole,C De Azevedo Marques Périco,Daniel P. Dickstein,Tom F.D. Farrow,Thomas Frodl,Thomas Frodl,Gregory R. Wagner,Ian H. Gotlib,Oliver Gruber,Byung Joo Ham,Dominic Job,Matthew J. Kempton,M J Kim,P C M P Koolschijn,Gin S Malhi,David Mataix-Cols,David Mataix-Cols,Andrew M. McIntosh,Allison C. Nugent,John T. O'Brien,John T. O'Brien,Stefania Pezzoli,Stefania Pezzoli,Mary L. Phillips,Perminder S. Sachdev,Giacomo Salvadore,Sudhakar Selvaraj,Andrew C. Stanfield,Alan J. Thomas,M.J.D. van Tol,N.J.A. van der Wee,Dick J. Veltman,Archie Young,Cynthia H.Y. Fu,Cynthia H.Y. Fu,Anthony J. Cleare,Danilo Arnone +45 more
TL;DR: The results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes, which has the potential to inform the development of diagnostic biomarkers for these conditions.
Journal ArticleDOI
Computational meta-analysis of statistical parametric maps in major depression
Danilo Arnone,Dominic Job,Sudhakar Selvaraj,Osamu Abe,Francesco Amico,Yuqi Cheng,Sean J. Colloby,John T. O'Brien,Thomas Frodl,Thomas Frodl,Ian H. Gotlib,Byung Joo Ham,M. Justin Kim,P. Cédric M. P. Koolschijn,Cintia A M Périco,Giacomo Salvadore,Alan J. Thomas,Marie-José van Tol,Nic J.A. van der Wee,Dick J. Veltman,Gerd Wagner,Andrew M. McIntosh +21 more
TL;DR: A novel voxel‐based technique is implemented that estimates and meta‐analyses between‐group differences in grey matter from individual MRI studies, which are then applied to the study of major depression.
Journal ArticleDOI
PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
Erica M. Richards,Paolo Zanotti-Fregonara,Masahiro Fujita,Laura E. Newman,Cristan Farmer,Elizabeth D. Ballard,Rodrigo Machado-Vieira,Rodrigo Machado-Vieira,Peixiong Yuan,Mark J. Niciu,Chul Hyoung Lyoo,Ioline D. Henter,Giacomo Salvadore,Wayne C. Drevets,Hartmuth C. Kolb,Robert B. Innis,Carlos A. Zarate +16 more
TL;DR: This study found a trend towards increased TSPO binding in the brains of MDD subjects, and post hoc analysis extended these findings by demonstrating that this abnormality is significant in unmedicated (but not medicated) MDDSubjects.
Journal ArticleDOI
Ketamine as a Fast Acting Antidepressant: Current Knowledge and Open Questions
Giacomo Salvadore,Jaskaran Singh +1 more
TL;DR: A critical overview of the knowledge gaps about the use of ketamine in depression is provided and some future research directions for the investigation of ketamines as a promising tool to develop novel more effective and fast acting antidepressants are suggested.
Journal ArticleDOI
The effects of interleukin-6 neutralizing antibodies on symptoms of depressed mood and anhedonia in patients with rheumatoid arthritis and multicentric Castleman’s disease
Yu Sun,D. Wang,Giacomo Salvadore,Benjamin Hsu,Mark E. Curran,Corey Casper,Jessica Vermeulen,Justine M. Kent,Jaskaran Singh,Wayne C. Drevets,Gayle M. Wittenberg,Guang Chen +11 more
TL;DR: The data together suggest that the IL-6 antibodies improve depressive symptoms in patients with rheumatoid arthritis and MCD through improving primary disease dependent and independent mechanisms and the brain mechanisms underlying depressive symptom improvements.