G
Gianrico Farrugia
Researcher at Mayo Clinic
Publications - 493
Citations - 21305
Gianrico Farrugia is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Interstitial cell of Cajal & Gastroparesis. The author has an hindex of 71, co-authored 450 publications receiving 17810 citations. Previous affiliations of Gianrico Farrugia include Boston University & State University of New York System.
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Journal ArticleDOI
Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells
Christopher S. Reigstad,Charles E. Salmonson,John F. Rainey,Joseph H. Szurszewski,David R. Linden,Justin L. Sonnenburg,Gianrico Farrugia,Purna C. Kashyap +7 more
TL;DR: Gut microbiota acting through SCFAs are important determinants of enteric 5‐HT production and homeostasis through an effect of short‐chain fatty acids on enterochromaffin cells.
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Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Steven Vernino,Phillip A. Low,Robert D. Fealey,John D. Stewart,Gianrico Farrugia,Vanda A. Lennon +5 more
TL;DR: Seropositivity for antibodies that bind to or block ganglionic acetylcholine receptors identifies patients with various forms of autoimmune autonomic neuropathy and distinguishes these disorders from other types of dysautonomia.
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Complex Interactions Among Diet, Gastrointestinal Transit, and Gut Microbiota in Humanized Mice
Purna C. Kashyap,Purna C. Kashyap,Angela Marcobal,Luke K. Ursell,Muriel H. Larauche,Henri Duboc,Kristen A. Earle,Erica D. Sonnenburg,Jessica A. Ferreyra,Steven K. Higginbottom,Mulugeta Million,Yvette Taché,Pankaj J. Pasricha,Rob Knight,Rob Knight,Gianrico Farrugia,Justin L. Sonnenburg +16 more
TL;DR: Diet can affect GI transit through microbiota-dependent or microbiota-independent pathways, depending on the type of dietary change, and the effect of the microbiota on transit largely depends on the amount and type of polysaccharides present in the diet.
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Decreased interstitial cell of Cajal volume in patients with slow-transit constipation
Chong–Liang He,Larry Burgart,Linan Wang,John H. Pemberton,Tonia Young Fadok,Joseph H. Szurszewski,Gianrico Farrugia +6 more
TL;DR: In this article, the volume of interstitial cells of Cajal was determined in the normal sigmoid colon and in patients with slow transit constipation from patients who were stained with antibodies to protein gene product 9.5, c-kit and α-smooth muscle actin.
Journal ArticleDOI
Interstitial cells of Cajal in health and disease.
TL;DR: This review will describe what is known about the function and role of ICC both in health and in a variety of motility disorders with a focus on unresolved issues pertaining to their role in the control of gastrointestinal motility.