G
Gilles Pagès
Researcher at French Institute of Health and Medical Research
Publications - 403
Citations - 25339
Gilles Pagès is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Quantization (signal processing) & MAPK/ERK pathway. The author has an hindex of 73, co-authored 398 publications receiving 22584 citations. Previous affiliations of Gilles Pagès include Paul Sabatier University & French Institute for Research in Computer Science and Automation.
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Journal ArticleDOI
Targeted therapies in breast cancer: New challenges to fight against resistance.
Viviana Masoud,Gilles Pagès +1 more
TL;DR: The main scope of this review is to provide a thorough update of recent developments in the field and discuss future prospects for preventing resistance mechanisms in the quest to increase overall survival of patients suffering from the disease.
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A quantization tree method for pricing and hedging multidimensional american options
TL;DR: The quantization method is presented, which is well‐adapted for the pricing and hedging of American options on a basket of assets and results concerning the orders of the approximation with respect to the regularity of the payoff function and the global size of the grids are provided.
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The dual-specificity MAP kinase phosphatases: critical roles in development and cancer
TL;DR: Understanding how these phosphatases are themselves regulated during development or in physiological and pathological conditions is therefore fundamental and over the years, gene deletion and knockdown studies have completed initial in vitro studies and shed a new light on the global and specific roles of DUSPs in vivo.
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Signaling angiogenesis via p42/p44 MAP kinase and hypoxia.
Edurne Berra,Julie Milanini,Darren E. Richard,Maude Le Gall,Francesc Viñals,Emmanuel Gothié,Danièle Roux,Gilles Pagès,Jacques Pouysségur +8 more
TL;DR: It is demonstrated that p42/p44 MAP kinases play a pivotal role in angiogenesis by exerting a determinant action at three levels, and a model which suggests an autoregulatory feedback mechanism controlling HIF-1 alpha and therefore Hif-1-dependent gene expression is proposed.
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Inhibition of the Mitogen-activated Protein Kinase Pathway Triggers B16 Melanoma Cell Differentiation
Walter Englaro,Corine Bertolotto,Roser Buscà,Anne Brunet,Gilles Pagès,Jean-Paul Ortonne,Robert Ballotti +6 more
TL;DR: Results demonstrate that the MAP kinase pathway activation is not required for cAMP-induced melanogenesis, and the inhibition of this pathway induces B16 melanoma cell differentiation, while a sustained activation impairs the melanogenic effect of cAMP -elevating agents.