R
Robert Ballotti
Researcher at French Institute of Health and Medical Research
Publications - 187
Citations - 12536
Robert Ballotti is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Melanoma & Microphthalmia-associated transcription factor. The author has an hindex of 60, co-authored 185 publications receiving 11370 citations. Previous affiliations of Robert Ballotti include University of Nice Sophia Antipolis & Max Planck Society.
Papers
More filters
Journal ArticleDOI
Cyclic AMP a Key Messenger in the Regulation of Skin Pigmentation
Roser Buscà,Robert Ballotti +1 more
TL;DR: It appears that melanogenic gene expression is controlled by a complex network of regulation involving other transcription factors such as Brn2, TBX2, PAX3 and SOX10, which would finally allow a fine tuning of melanocyte differentiation leading to melanin synthesis.
Journal ArticleDOI
Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes
Corine Bertolotto,Patricia Abbe,Timothy J. Hemesath,Karine Bille,David E. Fisher,Jean-Paul Ortonne,Robert Ballotti +6 more
TL;DR: The mechanism by which cAMP stimulates tyrosinase expression and melanogenesis is disclosed and the critical role of microphthalmia as signal transducer in cAMP-induced melanogenesis and pigment cell differentiation is emphasized.
Journal ArticleDOI
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
Corine Bertolotto,Fabienne Lesueur,Sandy Giuliano,Thomas Strub,Mahaut de Lichy,Karine Bille,Philippe Dessen,Benoit d’Hayer,Hamida Mohamdi,Audrey Remenieras,Eve Maubec,Arnaud de la Fouchardière,Vincent Molinié,Pierre Vabres,Stéphane Dalle,N. Poulalhon,Tanguy Martin-Denavit,Luc Thomas,Pascale Andry-Benzaquen,Nicolas Dupin,F. Boitier,Annick Rossi,Jean-Luc Perrot,Bruno Labeille,Caroline Robert,Bernard Escudier,Olivier Caron,Laurence Brugières,Simon Saule,Betty Gardie,Sophie Gad,Stéphane Richard,Jérôme Couturier,Bin Tean Teh,Paola Ghiorzo,Lorenza Pastorino,Susana Puig,Celia Badenas,Håkan Olsson,Christian Ingvar,Etienne Rouleau,Rosette Lidereau,Philippe Bahadoran,Philippe Vielh,Eve Corda,Hélène Blanché,Diana Zelenika,Pilar Galan,François Aubin,Bertrand Bachollet,Celine Becuwe,Pascaline Berthet,Yves-Jean Bignon,Valérie Bonadona,Jean -Louis Bonafe,Marie -Noelle Bonnet-Dupeyron,Frédéric Cambazard,Jacqueline Chevrant-Breton,Isabelle Coupier,Sophie Dalac,Liliane Demange,Michel D'Incan,Catherine Dugast,Laurence Faivre,Lynda Vincent-Fetita,Marion Gauthier-Villars,Brigitte Gilbert,Florent Grange,Jean-Jacques Grob,Philippe Humbert,Nicolas Janin,Pascal Joly,Delphine Kerob,Christine Lasset,Dominique Leroux,Julien Levang,Jean -Marc Limacher,Cristina Bulai Livideanu,Michel Longy,Alain Lortholary,Dominique Stoppa-Lyonnet,Sandrine Mansard,Ludovic Mansuy,Karine Marrou,Christine Mateus,Christine Maugard,Nicolas Meyer,Catherine Noguès,Pierre Souteyrand,Laurence Venat-Bouvet,Hélène Zattara,Valérie Chaudru,Gilbert M. Lenoir,Mark Lathrop,Irwin Davidson,Marie-Françoise Avril,Florence Demenais,Robert Ballotti,Brigitte Bressac-de Paillerets +98 more
TL;DR: A germline missense substitution in MITF (Mi-E318K) is identified that occurred at a significantly higher frequency in genetically enriched patients affected with melanoma, RCC or both cancers, when compared with controls and provides insights into the link between SUMOylation, transcription and cancer.
Journal ArticleDOI
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes.
Roser Buscà,Patricia Abbe,F. Mantoux,Edith Aberdam,Carole Peyssonnaux,Alain Eychène,Jean-Paul Ortonne,Robert Ballotti +7 more
TL;DR: It is shown that Ras, but not Ras, is activated cell‐specifically and mediates the cAMP‐dependent activation of ERKs, while Rap‐1 is not involved in this process in melanocytes, suggesting the existence of a melanocyte‐specific Ras exchange factor directly regulated by cAMP.
Journal ArticleDOI
Fifteen‐year quest for microphthalmia‐associated transcription factor target genes
TL;DR: An overview of the MITF‐regulated genes is provided and special attention is paid to theMITF target genes in melanocytes and questions about target specificity are raised.