G
Gillian Morrison
Researcher at University of Edinburgh
Publications - 27
Citations - 1382
Gillian Morrison is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 14, co-authored 23 publications receiving 1115 citations. Previous affiliations of Gillian Morrison include University of Cambridge & Western General Hospital.
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Journal ArticleDOI
Characterization of the mouse beta defensin 1, Defb1, mutant mouse model
TL;DR: Beta defensins are small cationic antimicrobial peptides present in the respiratory system which have been proposed to be dysfunctional in the environment of the cystic fibrosis lung and a role for these peptides in resistance to urinary tract infection is suggested.
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Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development
TL;DR: It is concluded that the unique ability of Oct4 to maintain ES cell pluripotency is derived from an ancestral function of this class of proteins to maintain multipotency.
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Anterior Definitive Endoderm from ESCs Reveals a Role for FGF Signaling
Gillian Morrison,Ifigenia Oikonomopoulou,Rosa Portero Migueles,Shamit Soneji,Alessandra Livigni,Tariq Enver,Joshua M. Brickman +6 more
TL;DR: Findings in defined monolayer differentiation suggest FGF signaling is an important regulator of early anterior mesendoderm differentiation rather than merely a mediator of morphogenetic movement.
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Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Ester Gangoso,Benjamin Southgate,Leanne Bradley,Stefanie Rus,Felipe Gálvez-Cancino,Niamh McGivern,Esra Güç,Chantriolnt-Andreas Kapourani,Adam Byron,Kirsty M. Ferguson,Neza Alfazema,Gillian Morrison,Vivien Grant,Carla Blin,IengFong Sou,Maria Angeles Marques-Torrejon,Lucia Conde,Simona Parrinello,Javier Herrero,Stephan Beck,Sebastian Brandner,Paul Brennan,Paul Bertone,Jeffrey W. Pollard,Sergio A. Quezada,Duncan Sproul,Margaret C. Frame,Alan Serrels,Steven M. Pollard +28 more
TL;DR: In this paper, the authors explore the mechanisms underlying immune evasion in GBM by serially transplanting GBM stem cells into immunocompetent hosts, uncovering an acquired capability of GSCs to escape immune clearance by establishing an enhanced immunosuppressive tumor microenvironment.
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Rapid sequence divergence in mammalian β-defensins by adaptive evolution
TL;DR: Analysis of largest murine and human clusters of beta-defensin genes concludes that the locus has evolved by successive rounds of duplication followed by substantial divergence involving positive selection, to produce a diverse cluster of paralogous genes prior to human-baboon divergence.