J
Joshua M. Brickman
Researcher at University of Copenhagen
Publications - 76
Citations - 4590
Joshua M. Brickman is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 34, co-authored 67 publications receiving 4055 citations. Previous affiliations of Joshua M. Brickman include National Institute for Medical Research & Medical Research Council.
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Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
Mehul T. Dattani,Juan Pedro Martinez-Barbera,Paul Q. Thomas,Joshua M. Brickman,Raj Gupta,Inga-Lill Mårtensson,Håkan Toresson,Margaret Fox,Jerry Wales,Peter C. Hindmarsh,Stefan Krauss,Rosa S. P. Beddington,Iain C. A. F. Robinson +12 more
TL;DR: An important role for Hesx1/HESX1 in forebrain, midline and pituitary development in mouse and human is suggested.
Journal ArticleDOI
Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia
Paul Q. Thomas,Mehul T. Dattani,Mehul T. Dattani,Joshua M. Brickman,David E. G. McNay,Garry L. Warne,Margaret Zacharin,Fergus J. Cameron,Jane Hurst,Katie Woods,David B. Dunger,Richard Stanhope,Susan M. Forrest,Iain C.A.F. Robinson,Rosa S.P. Beddington +14 more
TL;DR: In this article, the HESX1/Hesx1 homozygous mutations were detected in individuals with relatively mild pituitary hypoplasia or SOD, which display incomplete penetrance and variable phenotype amongst heterozygous family members.
Journal ArticleDOI
Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Brian T. Weinert,Takeo Narita,Shankha Satpathy,Balaji Srinivasan,Bogi Karbech Hansen,Christian Schölz,William B. Hamilton,Beth E. Zucconi,Wesley W. Wang,Wenshe R. Liu,Joshua M. Brickman,Kesicki Edward A,Albert Lai,Kenneth D. Bromberg,Philip A. Cole,Chunaram Choudhary +15 more
TL;DR: This work combined quantitative proteomics with CBP/p300-specific catalytic inhibitors, bromodomain inhibitor, and gene knockout to reveal a comprehensive map of regulated acetylation sites and their dynamic turnover rates, revealing a dynamic balance between acetylations and deacetylation.
Journal ArticleDOI
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript.
TL;DR: Detection of low-level, lineage-specific transcription aids in the identification of lineage-primed populations of ES cells provides a new framework for pluripotency.
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An HMG-like protein that can switch a transcriptional activator to a repressor
TL;DR: A Drosophila HMG1 protein is described, called DSP1 (dorsal switch protein), that converts Dorsal and NF-κB from transcriptional activators to repressers and can determine whether a specific regulator functions as an activator or a repressor of transcription.