G
Giorgia Federico
Researcher at University of Naples Federico II
Publications - 16
Citations - 459
Giorgia Federico is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Erythropoiesis & Ferritin. The author has an hindex of 8, co-authored 15 publications receiving 262 citations.
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Journal ArticleDOI
NCOA4 Deficiency Impairs Systemic Iron Homeostasis.
Roberto Bellelli,Giorgia Federico,Alessandro Matte,David Colecchia,Achille Iolascon,Mario Chiariello,Massimo Santoro,Lucia De Franceschi,Francesca Carlomagno +8 more
TL;DR: It is shown that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and spleen, increased levels of transferrin saturation, serum ferritin, and liver hepcidin, etc, and decreased levels of duodenal ferroportin.
Journal ArticleDOI
RET Gene Fusions in Malignancies of the Thyroid and Other Tissues.
TL;DR: The role of RET fusions in the pathogenesis of human cancer is summarized with the advent of highly sensitive massive parallel sequencing of tumor DNA or cell-free circulating tumor DNA.
Journal ArticleDOI
NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.
Antonella Nai,Maria Rosa Lidonnici,Giorgia Federico,Mariateresa Pettinato,Violante Olivari,Federica Carrillo,Simonetta Geninatti Crich,Giuliana Ferrari,Clara Camaschella,Laura Silvestri,Francesca Carlomagno +10 more
TL;DR: A major role is revealed for NCOA4-mediated ferritinophagy in macrophages to favor iron release for erythropoiesis, especially in iron deficiency.
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Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology
Brendan Frett,Francesca Carlomagno,Maria Luisa Moccia,Annalisa Brescia,Giorgia Federico,Valentina De Falco,Brittany Admire,Zhong-Zhu Chen,Zhong-Zhu Chen,Wenqing Qi,Massimo Santoro,Hong-yu Li +11 more
TL;DR: This study validates the effectiveness and usefulness of a medicinal chemistry/polypharmacology approach to obtain an inhibitor capable of targeting multiple oncogenic pathways.
Journal ArticleDOI
Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition
Rosa Sottile,Rosa Sottile,Giorgia Federico,Cinzia Garofalo,Rossana Tallerico,Maria Concetta Faniello,Barbara Quaresima,Costanza Maria Cristiani,Maddalena Di Sanzo,Gianni Cuda,Valeria Ventura,Arnika Kathleen Wagner,Gianluca Contrò,Nicola Perrotti,Elio Gulletta,Soldano Ferrone,Klas Kärre,Francesco Costanzo,Francesca Carlomagno,Ennio Carbone,Ennio Carbone +20 more
TL;DR: Iron depletion and FTH downregulation increased the target susceptibility of both primary cancer cells and macrophages to NK cell recognition and may influence the expression of MHC class I molecules leading to NK cells activation.