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Wen-Ming Chu
Researcher at Brown University
Publications - 29
Citations - 2693
Wen-Ming Chu is an academic researcher from Brown University. The author has contributed to research in topics: TLR9 & Transcription (biology). The author has an hindex of 21, co-authored 29 publications receiving 2545 citations. Previous affiliations of Wen-Ming Chu include University of California, Davis.
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Journal ArticleDOI
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.
Stanimir S. Ivanov,Ana M. Dragoi,Xin Wang,Corrado Dallacosta,Jennifer Louten,Giovanna Musco,Giovanni Sitia,George S. Yap,Yinsheng Wan,Christine A. Biron,Marco Bianchi,Haichao Wang,Wen-Ming Chu +12 more
TL;DR: The DNA-binding protein HMGB1 shuttles in and out of immune cells and regulates inflammatory responses to CpG-DNA.
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA Running title: Mechanism of TLR9 activation
Wen-Ming Chu,Giovanni Sitia,George S. Yap,Yinsheng Wan,Christine A. Biron,Marco Bianchi,Haichao Wang,Stanimir S. Ivanov,Ana-Maria Dragoi,Xin Wang,Corrado Dallacosta,Jennifer Louten,Giovanna Musco +12 more
TL;DR: In this paper, the authors identified HMGB1 as a CpG-ODN-binding protein, which interacts and pre-associates with TLR9 in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC), and hastens TLR 9's redistribution to early endosomes in response to CpGs-ODNs.
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Cell stress and translational inhibitors transiently increase the abundance of mammalian SINE transcripts
TL;DR: Together, these three species exemplify the known SINE composition of placental mammals, suggesting that mammalian SINEs are similarly regulated and may serve a common function.
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Potential Alu Function: Regulation of the Activity of Double-Stranded RNA-Activated Kinase PKR
TL;DR: The increased levels of Alu RNAs caused by cellular exposure to different stresses regulate protein synthesis by antagonizing PKR activation, which provides a functional role for mammalian short interspersed elements, prototypical junk DNA.
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High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells
TL;DR: The critical role of STAT4 levels in predisposing selection of specific signaling pathways is elucidated, the biological importance of regulation within particular cell lineages is defined, and mechanistic insights for how this is accomplished in vivo are provided.