G
Giovanna Tabellini
Researcher at University of Brescia
Publications - 87
Citations - 4906
Giovanna Tabellini is an academic researcher from University of Brescia. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Protein kinase B. The author has an hindex of 37, co-authored 83 publications receiving 4400 citations. Previous affiliations of Giovanna Tabellini include University of Trieste & Brescia University.
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Journal ArticleDOI
Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors
Silvia Codenotti,Daniela Zizioli,Luca Mignani,Sara Rezzola,Giovanna Tabellini,Silvia Parolini,Arianna Giacomini,Michela Asperti,Maura Poli,Delia Mandracchia,Marika Vezzoli,Simona Bernardi,Domenico Russo,Stefania Mitola,Eugenio Monti,Luca Triggiani,Davide Tomasini,Stefano Gastaldello,Matteo Cassandri,Rossella Rota,Francesco Marampon,Alessandro Fanzani +21 more
TL;DR: Restriction of glucose metabolism and the mevalonate pathway, in combination with standard therapy, may increase therapy success in RMS tumors characterized by a dysregulated Akt signaling.
Nuclear lipid signaling and cancer
Alberto M. Martelli,Lucia Manzoli,Anna Maria Billi,Giovanna Tabellini,Roberta Bortul,Daniela Peruzzi,Michela Aluigi,L. Cocco +7 more
TL;DR: There is now compelling evidence that agonist stimulation of a variety of cells results in the induction of specific changes in nuclear lipid metabolism, supporting the hypothesis of an important role of lipids in nuclear signal transduction.
Journal ArticleDOI
The Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway as a Therapeutic Target for the Treatment of Human Acute Myeloid Leukemia (AML)
Alberto M. Martelli,Giovanna Tabellini,Roberta Bortul,Maria Nyakern,Pier Luigi Tazzari,Camilla Evangelisti,Lucio Cocco +6 more
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FGF-trapping hampers cancer stem-like cells in uveal melanoma
Alessandra Loda,Stefano Calza,Arianna Giacomini,Cosetta Ravelli,Adwaid Manu Krishna Chandran,Chiara Tobia,Giovanna Tabellini,Silvia Parolini,Francesco Semeraro,Roberto Ronca,Sara Rezzola +10 more
TL;DR: In this paper , a hierarchical clustering of gene expression data publicly available on The Cancer Genome Atlas (TCGA) was performed to identify patients' clusters, which revealed a strong correlation between FGF/FGFRs and stemness-related genes.
Journal ArticleDOI
CARD11 dominant negative mutation leads to altered human Natural Killer cell homeostasis.
Manuela Baronio,Luisa Gazzurelli,Sara Rezzola,Stefano Rossi,Giulio Tessarin,Maddalena Marinoni,Michele Fiore,Daniele Moratto,Marco Chiarini,Raffaele Badolato,Silvia Parolini,Giovanna Tabellini,Vassilios Lougaris +12 more
TL;DR: In this article , a 12-year-old boy with severe atopic dermatitis, food induced anaphylaxis and hypogammaglobulinemia harboring a novel de novo heterozygous variant c.169G > A; p.Glu57Lys in CARD11 was confirmed on both CD4+ and CD8+ and CTLA4+Foxp3+CD4+ Tregs were severely reduced.