Gitte Neubauer

TL;DR: The U1 snRNP is essential for recognition of the pre-mRNA 5'-splice site and the subsequent assembly of the spliceosome and it is shown that Nam8p/Mud15p contributes to the stability of U1snRNP.

TL;DR: A fifth protein in the H complex peak, corresponding to hnRNP P2, is shown to be the product of the TLS/FUS gene, which was originally identified as a chimeric oncogene formed by the chromosome translocation t(12;16) that is responsible for myxoid liposarcoma.

TL;DR: High-throughput chemoproteomics method enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts resulted in CZC24832, which is to the authors' knowledge the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation.

TL;DR: This mutation to glutamine in the E65Q variant of leishmania TIM results in much higher stability; for example, at pH 7, the apparent melting temperature increases by 26 degrees C and this mutation does not affect the kinetic properties, showing that even point mutations can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power at the Mesophilic temperature.

TL;DR: Quantitative chemoproteomic profiling shows that LY294002 and LY303511 inhibit the BET bromodomain proteins BRD2, BRD3, and BRD4 that comprise a family of targets structurally unrelated to PI3K.