Giulia Bolasco

TL;DR: It is shown that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice and this work suggests that deficits in microglian function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.

TL;DR: It is shown that deficient synaptic pruning is associated with weak synaptic transmission, decreased functional brain connectivity, deficits in social interaction and increased repetitive-behavior phenotypes that have been previously associated with autism and other neurodevelopmental and neuropsychiatric disorders.

TL;DR: This study shows direct evidence of microglia-synapse interaction wheremicroglia do not necessarily ‘eat’ post- synapse structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.

TL;DR: Mice generated with a targeted deletion of Atat1 have a conserved function as the major α-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules.

TL;DR: Light sheet fluorescence microscopy is used to follow microglia-synapse interactions in developing organotypic hippocampal cultures and this work proposes a mechanism for the facilitatory role of micro glial cells in synaptic circuits remodeling and maturation.