G
Giulia Maria Sancesario
Researcher at University of Rome Tor Vergata
Publications - 62
Citations - 1923
Giulia Maria Sancesario is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Dementia & Amyloid beta. The author has an hindex of 21, co-authored 56 publications receiving 1384 citations.
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Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease
Claudio Liguori,Andrea Romigi,Marzia Nuccetelli,S. Zannino,Giuseppe Sancesario,Alessandro Martorana,Maria Albanese,Nicola Biagio Mercuri,Francesca Izzi,Sergio Bernardini,Alessandra Nitti,Giulia Maria Sancesario,Francesco Sica,Maria Grazia Marciani,Fabio Placidi +14 more
TL;DR: The results demonstrate that, in AD, increased cerebrospinal fluid orexin levels are related to a parallel sleep deterioration, which appears to be associated with cognitive decline.
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Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease.
Giovanni Monteleone,Massimo Fantini,Sara Onali,Francesca Zorzi,Giulia Maria Sancesario,Sergio Bernardini,Emma Calabrese,Francesca Viti,Ivan Monteleone,Livia Biancone,Francesco Pallone +10 more
TL;DR: The study shows for the first time that GED0301 is safe and well tolerated in patients with active CD, and reduces the percentage of inflammatory cytokine-expressing CCR9-positive T cells in the blood.
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Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease
Paraskevi Krashia,Alberto Cordella,Annalisa Nobili,Livia La Barbera,Mauro Federici,Alessandro Leuti,Federica Campanelli,Giuseppina Natale,Gioia Marino,Valeria Calabrese,Francescangelo Vedele,Veronica Ghiglieri,Barbara Picconi,Giulia Di Lazzaro,Tommaso Schirinzi,Giulia Maria Sancesario,Nicolas Casadei,Olaf Riess,Sergio Bernardini,Antonio Pisani,Paolo Calabresi,Maria Teresa Viscomi,Charles N. Serhan,Valerio Chiurchiù,Marcello D'Amelio,Nicola Biagio Mercuri +25 more
TL;DR: Rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation, suggesting there is an imbalance between neuroinflammatory and pro-resolving processes in PD.
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Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration.
Silvia Rossi,Caterina Motta,Valeria Studer,Francesca Barbieri,Fabio Buttari,Alessandra Bergami,Giulia Maria Sancesario,Sergio Bernardini,Gottardo De Angelis,Gianvito Martino,Roberto Furlan,Diego Centonze +11 more
TL;DR: The results point to TNF as a primary neurotoxic molecule in progressive forms of MS and suggest a pathogenic role of B cells in TNF CSF increase, exacerbation of glutamatergic transmission and neuronal damage.
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CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease
Claudio Liguori,Alessandro Stefani,Giuseppe Sancesario,Giulia Maria Sancesario,Maria Grazia Marciani,Mariangela Pierantozzi +5 more
TL;DR: A dynamic relationship between neuronal energy metabolism, τ proteins and cognitive decline in AD is suggested and the clinical potential of assessing CSF lactate levels in patients with AD is proposed to better define the neuronal brain metabolism damage.