Alessandro Stefani

TL;DR: Recommendations are provided to patients, physicians, and other health care providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD) to be considered in a select group of appropriate patients.

TL;DR: Findings indicate that, in patients with advanced Parkinson's disease, PPN-DBS associated with standard STN- DBS may be useful in improving gait and in optimizing the dopamine-mediated ON-state, particularly in those whose response to STN only DBS has deteriorated over time.

TL;DR: The first surgical exploration and implantation of deep brain stimulating electrodes of the peduncolopontine nucleus area in two Parkinson's disease patients to examine the safety and the potential benefit of chronic electrical stimulation at this site are reported.

TL;DR: These findings argue that, contrary to a strict receptor segregation hypothesis, many striatonigral neurons colocalize functional D1, D2, and D3 receptors.

TL;DR: Parkinson-associated physiopathological modifications were characterized in six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive to complementary tissue characteristics, demonstrating that multimodal magnetic resonance imaging of sub cortical grey matter structures is useful for the evaluation of Parkinson's disease and, possibly, of other subcortsical pathologies.