Gleb Bezgin

TL;DR: An overarching organization of large-scale connectivity that situates the default-mode network at the opposite end of a spectrum from primary sensory and motor regions is described, suggesting that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.

TL;DR: The data suggest that the transient nature of FC is in part dependent on direct underlying structural connections, but also that dynamic coordination can occur via polysynaptic pathways, and further elucidate how large-scale dynamic functional coordination exists within a fixed structural architecture.

TL;DR: Together, the data directly demonstrate that the FC patterns observed in resting-state BOLD-fMRI are dictated by the underlying neuroanatomical architecture, and shows how this architecture contributes to the global organizational principles of both functional specialization and integration.

TL;DR: The data suggest that the stability of those functional interactions is mediated in part by the direct anatomical projections of large, highly myelinated fibers that traverse the corpus callosum, suggesting a preserved framework for interhemispheric communication despite an increase in functional lateralization in humans.

TL;DR: It is hypothesized that in the spontaneous condition the brain operates in a metastable regime where cortico-cortical projections target excitatory and inhibitory populations in a balanced manner that produces substantial inter-area interactions while maintaining global stability.