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Christine M. Dunham
Researcher at Emory University
Publications - 60
Citations - 3998
Christine M. Dunham is an academic researcher from Emory University. The author has contributed to research in topics: Ribosome & Translation (biology). The author has an hindex of 23, co-authored 53 publications receiving 3669 citations. Previous affiliations of Christine M. Dunham include Laboratory of Molecular Biology & University of California, Santa Cruz.
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Journal ArticleDOI
Structure of the 70S Ribosome Complexed with mRNA and tRNA
Maria Selmer,Christine M. Dunham,Frank V. Murphy,Albert Weixlbaumer,Sabine Petry,Ann C. Kelley,John R. Weir,Venki Ramakrishnan +7 more
TL;DR: The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (t RNA) and metal ions also stabilize the intersubunit interface.
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The structure of the ribosome with elongation factor G trapped in the posttranslocational state.
Yong-Gui Gao,Maria Selmer,Christine M. Dunham,Albert Weixlbaumer,Ann C. Kelley,Venki Ramakrishnan +5 more
TL;DR: A crystal structure refined to 3.6 angstrom resolution of the ribosome trapped with EF-G in the posttranslocational state using the antibiotic fusidic acid is reported, providing insights into translocation and decoding.
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Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein
Colin S. Burns,Eliah Aronoff-Spencer,Christine M. Dunham,Paula I. Lario,Nikolai I. Avdievich,William E. Antholine,Marilyn M. Olmstead,Alice Vrielink,Gary J. Gerfen,Jack Peisach,William G. Scott,Glenn L. Millhauser +11 more
TL;DR: The structure reveals an unusual complementary interaction between copper-structured HGGGW units that may facilitate molecular recognition between prion proteins, thereby suggesting a mechanism for transmembrane signaling and perhaps conversion to the pathogenic form.
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Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon.
Sabine Petry,Ditlev E. Brodersen,Frank V. Murphy,Christine M. Dunham,Maria Selmer,Michael J. Tarry,Ann C. Kelley,Venki Ramakrishnan +7 more
TL;DR: In this article, the crystal structures of the ribosome from Thermus thermophilus with RF1 and RF2 bound to their cognate stop codons, at the same time, were presented.
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The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
Cajetan Neubauer,Yong-Gui Gao,Kasper R. Andersen,Christine M. Dunham,Ann C. Kelley,Jendrik Hentschel,Kenn Gerdes,Venki Ramakrishnan,Ditlev E. Brodersen +8 more
TL;DR: Crystal structures of E. coli RelE in isolation and bound to programmed Thermus thermophilus 70S ribosomes before and after cleavage provide detailed insight into the translational regulation on the bacterial ribosome by mRNA cleavage.