Beatrice Sommer

TL;DR: This is the first report in which deficiency of a non-collagenous ECM protein leads to a skeletal phenotype that is marked by low bone mass that becomes more obvious with age and may serve as an animal model to study the role of ECM proteins in osteoporosis.

TL;DR: It is reported that bgn deficiency leads to structural abnormality in collagen fibrils in bone, dermis, and tendon, and to a “subclinical” cutaneous phenotype with thinning of the dermis but without overt skin fragility.

TL;DR: Differential display of DEX‐treated hBMSC revealed unique patterns of gene expression and has provided new information about phenotypic changes that accompany the differentiation of hB MSC toward osteogenesis.

TL;DR: Very efficient gene transfer into multilayered HMSF and HTB cell cultures was observed, and DNA coincubated with unmodified ADV failed to be effectively transferred, implying that the covalently bound PLL more effectively binds exogenous DNA, resulting in a highly efficient internalization event in both cell types.

TL;DR: This study identifies an important cis‐acting element in the BSP promoter that acts as a tissue‐specific enhancer of BSP expression in both osteoblasts and hypertrophic chondrocytes and is the first demonstration of a common regulatory mechanism utilized by both chondrobasts and osteoblast for the tissue‐restricted expression of the B SP gene.