Glenn M Eastwood

TL;DR: Treatment with intravenous vitamin C, hydrocortisone, and thiamine did not significantly improve the duration of time alive and free of vasopressor administration in patients with septic shock, suggesting that treatment with the combination does not lead to a more rapid resolution of septicshock.

TL;DR: Among ICU patients requiring mechanical ventilation, a strategy of stress ulcer prophylaxis with use of proton pump inhibitors vs histamine-2 receptor blockers resulted in hospital mortality rates of 18.3% vs 17.5%, respectively, however, study interpretation may be limited by crossover in the use of the assigned medication.

TL;DR: Point estimates for the treatment effect of conservative oxygen therapy on 90-day mortality raise the possibility of clinically important harm with this intervention in patients with sepsis; however, the post hoc analysis was not powered to detect the effects suggested and the data do not exclude clinically important benefit or harm fromconservative oxygen therapy in this patient group.

TL;DR: The current analytical performance of vitamin C HPLC methodologies are acceptable for the requirements of a high-dose vitamin C RCTs and the harmonisation of sample handling and processing procedures will further improve the reliability of current analytical methodologies.

TL;DR: In awake volunteers, keeping eyes open induces significant changes to SedLine-derived parameters, most likely due to increased EMG activity (e.g. eye blinking).