Fumitaka Yanase

TL;DR: Treatment with intravenous vitamin C, hydrocortisone, and thiamine did not significantly improve the duration of time alive and free of vasopressor administration in patients with septic shock, suggesting that treatment with the combination does not lead to a more rapid resolution of septicshock.

TL;DR: In this article, the authors compared the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock.

TL;DR: There is no consistent evidence that IV high-dose vitamin C therapy is more harmful than placebo in double-blind randomized controlled trials, however, reports of oxalate nephropathy, hypernatremia, glucometer error, and hemolysis in glucose-6-phosphate dehydrogenase deficiency patients warrant specific monitoring.

TL;DR: Intravenous vitamin C (1.5 g every 6 hours) corrects vitamin C deficiency and hypovitaminosis C and provides an appropriate dosing schedule to achieve and maintain normal or elevated vitamin C levels in septic shock.

TL;DR: Compared with early NUF rates <1.01 mL/kg/h, NUF Rates >1.75 mL/kg-h are associated with increased mortality, and these observations provide the rationale for clinical trials to confirm or refute these findings.