Michaela Gruber

TL;DR: It is demonstrated that Hif-2α plays a critical role in adult erythropoiesis, with acute deletion leading to anemia, and HIF-1α is the critical α isoform regulating Epo under physiologic and stress conditions in adults.

TL;DR: It is suggested that HIF-1alpha contributes to the regulation of growth factor-stimulated glucose metabolism even in the absence of hypoxia.

TL;DR: A role for BNip3 is identified in limiting mitochondrial mass and maintaining mitochondrial integrity in the liver that has consequences for lipid metabolism and disease.

TL;DR: It is suggested that cells committed to unregulated growth within ischemic tumor microenvironments are unable to balance lipid and protein synthesis due to a critical limitation in desaturated lipids.

TL;DR: This review summarizes recent studies on hypoxia-inducible factor-α functions in development and tumorigenesis and highlights the need to further characterize the specific roles of hypoxIA-induceable factor-1α and hypoxial-inducer factor-2α during tumorigenisation to design therapies targeting the relevant isoform for specific diseases.