Glenn S. Elliott

TL;DR: This 90-day/one-generation reproduction study with 17 beta-estradiol was designed to set dose levels for future multigenerational reproduction and combined chronic toxicity/oncogenicity studies, and to provide benchmark data for a risk assessment for chemicals with estrogen-like activities.

TL;DR: NMP was not oncogenic in male or female rats at dietary concen trations of 15000 ppm and below and there were no adverse, test substance-related effects on the incidences of clinical observations, food consumption, body weight, differential leukocyte counts, red blood cell morphology, or survival in either males or females at any dietary concentration.

TL;DR: Chronic exposure to WY causes liver alterations such as cholestasis, which may increase plasma concentrations of CCK, and the absence of any early pancreas changes in the subchronic study is consistent with the in vitro data which demonstrated that WY is not a CCK(A) agonist or a trypsin inhibitor.

TL;DR: A functional assay for assessing humoral immunity may be conducted in animals on standard toxicology study after it was found that administration of SRBC did not mask the immunosuppressive effects of CY treatment under the conditions of this study.

TL;DR: Dimethylformamide was not oncogenic under these experimental conditions in either the rat or mouse.