Gong Chen

TL;DR: Efficient methods have been developed to synthesize azetidine, pyrrolidine, and indoline compounds via palladium-catalyzed intramolecular amination of C-H bonds at the γ and δ positions of picolinamide (PA) protected amine substrates, highlighting the use of unactivated C- H bond, especially the C(sp(3))-H bond of methyl groups, as functional groups in organic synthesis.

TL;DR: P palladium-catalyzed bidentate auxiliary-directed C-H functionalization reactions for αAA substrates enable new retrosynthetic logic for the synthesis of many basic αAAs from a common alanine precursor and may facilitate the efficient total synthesis of complex peptide natural products.

TL;DR: These reactions provide a convenient and straightforward method for the preparation of high-value N-containing products from readily available amine and alkyl iodide precursors.

TL;DR: A practical synthetic strategy based on the picolinamide-directed palladium-catalyzed arylation and alkenylation of the remote C(sp) H bonds of a variety of aliphatic substrates under mild conditions and the application of this transformation to the formal synthesis of (+)-obafluorin is reported.

TL;DR: The efficient synthesis of alkyl ethers is reported by the functionalization of unactivated sp(3)- and sp(2)-hybridized C-H bonds, particularly the C(sp(3))-H bond of methyl groups, as functional groups in organic synthesis.